Chimeric Toxins : Mechanisms of Action and Therapeutic Applications

ISBN-13: 9780415283861 / Angielski / Twarda / 2002 / 292 str.

Lorberboum-Galski Lorberboum-Galski; Haya Lorberboum-Galaski; Philip Lazarovici

Opis

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells such as binding to specific surface receptors, internalization and translocation across the cell membrane and interaction with intra-cellular components. Because of their potency in killing eukaryotic cells, they have been used in the development of novel agents for targeted immunotherapy and have been termed chimeric toxins.

Spis treści

Bacterial and Plant Toxins - General Mode of Action. Diphtheria Toxin-Structure, Function and its Therapeutic Use. Ricin A-Structure, Function and its Clinical Applications. Pathways of Delivering Toxins into the Cytosol of Target Cells. Engineering Immunotoxins for Improving their Therapeutic Activity. Ligand-receptor Interactions Studied with Chimeric Proteins. Chimeric Proteins: a Novel Approach for Eliminating Specific Cell Populations for Targeted Human Therapy. Chimeric Neurotoxins - a Molecular Neurosurgery Approach. Targeted Immunotherapy of Autoimmune Diseases by Chimeric Toxins. Immunotoxins for Targeted Cancer Therapy. Molecular Targeting of Brain Tumors with Cytotoxins. Toxins in the Development of Vaccines.

O autorze

Haya Lorberboum-Galski, Philip Lazarovici