Chemotherapy in Neonates and Infants: Pharmacological Oncology for Children Under 1 Year Old

ISBN-13: 9783319705903 / Angielski / Miękka / 2018 / 198 str.

Carolina Witchmichen Penteado Schmidt

Opis

This book provides a comprehensive overview of pediatric oncology, discussing drug therapy and treatment in children under the age of 1 year.

Recenzje

"This pocket size book is an important, comprehensive and updated review on the optimal use of chemotherapy in this very young age." (Pediatric Endocrinology Reviews (PER), Vol. 16 (1), September, 2018)

"This is a relatively unique pocket guide to chemotherapy in this young population. It is well written and organized and will be of help to professionals caring for neonates and infants with these rare malignancies." (Jay P. Goldsmith, Doody's Book Reviews, July, 2018)

Spis treści

1. Introduction

1.1. Differences of drug metabolism in neonates

1.2. Differences of drug metabolism in infants

1.3. Chemotherapy in neonates

1.4. Chemotherapy in infants

1.5. Statistics of the diseases in neonates and infants in each continent

1.6. Statistics of Oncohematology treatment of neonates and infants

2. Protocols used in chemotherapy treatment of neonates and infants 

3. Pharmacokinetics of Chemotherapy Drugs in Neonates and Infants 

3.1. Absorption of chemotherapy in Neonates and Infants 

3.2. Drug Binding and Distribution by Proteins 

3.2.1. Binding Proteins in Neonates 

3.2.2. Binding Proteins in Infants 

3.2.3. Transport Proteins in Neonates 

3.2.4. Transport Proteins in Infants 

3.3. Biotransformation by Enzyme Complexes 

3.3.1. Enzyme Complexes in Neonates 

3.3.2. Enzyme Complexes in Infants 

3.3.3. Enzymes which metabolizes chemotherapy - Which can be used when 

3.4. Excretion of Hydrosoluble Drugs

3.4.1. Creatinine clearance in Neonates

3.4.2. Creatinine clearance in Infants

3.4.3. pH urinary in Neonates and Infants

3.4.4. Tubular Secretion

3.4.5. Urinary flow in Neonates and Infants

3.5. Excretion of Liposoluble Drugs

4. Pharmacodinamics of Chemotherapy Drugs in Neonates and Infants

4.1. Receptors of Chemotherapy Drugs in Neonates

4.2. Receptors of Chemotherapy Drugs in Infants

4.3. Signaling in Neonates

4.4. Signaling in Infants

4.5. Therapeutic Index in Neonates and Infants

4.6. Dose-Response Relation in Neonates 

4.7. Dose-Response Relation in Infants

5. List of Chemotherapy Drugs in Neonates and Infants 

6. List of Adjuvant Drugs in Chemotherapy of Neonates and Infants 

7. Drug Interactions in Neonates and Infants 

8. Toxicity 

9. Tumor Lysis in Neonates and Infants

10. Chemotherapy in Neonates and Infants with Congenital Diseases 

11. Bone Marrow Transplantation in Neonates and Infants

11.1. Bone Marrow Transplantation in Neonates

11.2. Bone Marrow Transplantation in Infants

12. Body Surface of Neonates

13. Body Surface of Infants

14. Glossary

O autorze

Carolina Witchmichen Penteado Schmidt is an oncology pharmacist with extensive experience in Pediatric Oncohematology and Chemotherapy in Children.  She is a specialist in Oncological Hospital Pharmacy and also has an MBA in Business Management. She has extensive hospital experience in the field of Pharmacy, Drug Interactions, Pediatrics, Oncology, Hematology, Neonatology, Intensive Health Care and Infectology; and academic experience teaching medical residents of Pediatric Oncohematology program, also pharmacists residents of Child and Adolescent Health program, and teaching in post graduation courses. She is author of the book Drug Therapy and Interactions in Pediatric Oncology, published by Springer.

Blurb

This book provides a comprehensive overview of pediatric oncology, discussing drug therapy and treatment in children under the age of 1 year. It is the first volume to focus on chemotherapy in newborns and infants, especially the daily clinical practice and treatment protocols.

Intended as a practical manual, it addresses all the major topics related to pediatric oncology in an accessible and easy-to-use format. It examines topics in pediatric oncology therapeutics, including drug metabolism, excretion, toxicity, drugs that can be used for each week or month of the patient’s life, dose adjustment and treatment protocols.

Chemotherapy in Neonates and Infants focuses on the safe treatment of children in the first year of life, and is aimed at pediatric oncology/hematology institutions, clinics and departments. It is particularly valuable for researchers, pediatric oncology physicians, pediatric and neonatology physicians, oncology pharmacists and the other healthcare professionals directly involved in the chemotherapy of neonates and infants.