Chemotherapeutic Targets in Parasites: Contemporary Strategies

ISBN-13: 9780521620659 / Angielski / Twarda / 2002 / 242 str.

California) Tag E. Mansour (Stanford University;Joan MacKinnon Mansour

Opis

Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets. There are sections discussing helminths; including metabolic, neuromuscular, microtubular and tegumental targets. The design of more selective and less toxic drugs is emphasized throughout.

Recenzje

'Students of parasitology, research workers interested in drug development and practitioners in tropical medicine will find this book an invaluable guide to the theory of the chemical treatment of parasitic infections.' Chemistry in Australia

Spis treści

Preface; 1. The search for antiparasitic agents; 2. Biophysical, genomic, and proteomic analysis of drug targets; 3. Energy metabolism in parasitic helminths: targets for antiparasitic agents; 4. Antimalarial agents and their targets; 5. Antitrypanosomal and antileishmanial targets; 6. Targets in amitochondrial protists; 7. Neuromuscular structures and microtubules as targets; 8. Targets in the teguments of flatworms; Index.