Chemosensitivity Testing in Oncology

ISBN-13: 9783540434689 / Angielski / Twarda / 2002 / 245 str.

U. Reinhold; W. Tilgen; Uwe Reinhold

Opis

The 1990s saw a renaissance of the concept of individualized chemotherapy in oncology, markedly stimulated by the development of in vitro chemosensitivity assays. The clinical utility of drug response assays has been evaluated in clinical trials and the results suggest that assay-assisted therapy selection may improve survival as well as economic outcomes. This volume comprises the proceedings of the first Symposium of the International Society for Chemosensitivity Testing in Oncology, ISCO-1, held in Homburg/Saar, Germany, in September 2001. The topics include: in vitro drug-testing methods, tumor chemosensitivity assays, and the clinical relevance of assay-directed therapy.

Spis treści

1 In Vitro Drug Testing Methods: Recent Developments.- Luminescence Applications for Chemotherapeutic Drug Development.- The Use of the MTT Assay to Study Drug Resistance in Fresh Tumour Samples.- Chemosensitivity Testing of Human Tumors Using Si-sensor Chips.- Multiparametric Sensor Chips for Chemosensitivity Testing of Sensitive and Resistant Tumor Cells.- Development of New In Vitro Chemosensitivity Test Using Collagen Gel Droplet Embedded Culture and Image Analysis for Clinical Usefulness.- In Vitro Chemosensitivity Testing of Hematological Cancer Patients: Detection of Ornithine Decarboxylase.- 2 Tumor Chemosensitivity Assays: Evaluation of In Vitro Results.- The Chemosensitivity Profile of Retinoblastoma.- Chemosensitivity Testing in Malignant Melanoma.- Human Melanoma: Drug Resistance.- Cisplatin, Doxorubicin and Paclitaxel Induce mdr1 Gene Transcription in Ovarian Cancer Cell Lines.- 3 Clinical Relevance of Tumor-Directed Therapy.- Chemosensitivity Testing as an Aid to Anti-Cancer Drug and Regimen Development.- Assay-Assisted Treatment Selection for Women with Breast or Ovarian Cancer.- Chemosensitivity Testing in Gynecologic Oncology — Dream or Reality?.- Treosulfan in the Treatment of Metastatic Melanoma: From Chemosensitivity Testing to Clinical Trials.- Chemosensitivity Testing and Test-Directed Chemotherapy in Human Pancreatic Cancer.- Clinical Significance of Cellular Drug Resistance in Childhood Leukemia.- ATP Chemosensitivity Testing in Ovarian and Breast Cancer: Early Clinical Trials.- Chemosensitivity Testing — Present and Future in Japan.