Chemical Modification of Biological Polymers

ISBN-13: 9780367382414 / Angielski / Miękka / 2019 / 426 str.

Roger L. Lundblad

Opis

Examining the chemical modification of biological polymers and the emerging applications of this technology in the field of biotechnology, this book reflects the change in emphasis from the study of protein structure/function toward applications in therapeutics and diagnostics. It begins with a review of the basic science involved, including the underlying organic chemistry, the use of various chemical reagents, and the chemical modification of nucleic acids, carbohydrates, and proteins. It then discusses the characterization of non-enzymatic chemical modification of biopolymers and the use of chemical modification to produce biotechnology products.

Spis treści

Functional groups in Biological Polymers and Factor Governing Reactivity. Modification of Amino Groups in Proteins. Modification of Hydroxyl and Carboxyl Groups in Proteins. Modification of Imidazole and Indole Groups in Proteins. Modification of Sulfur-Containing Groups in Proteins. Modification of Nucleic Acids. Modification of Polysaccharides. In Vivo Non-enzymatic chemical modification of biological polymers. Proteomic Methods for the Analysis of the Modification of Biological Polymers. Chemical Methods for the Preparation of Conjugates of Biological Polymers.

O autorze

Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD in biochemistry at the University of Washington. After postdoctoral work in the laboratories of Stanford Moore and William Stein at The Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He joined the Hyland Division of Baxter Healthcare in 1990. Currently, Dr. Lundblad works as an independent consultant at Chapel Hill, North Carolina, and writes on biotechnological issues. He is also an adjunct professor of pathology at the University of North Carolina.