Characterization of Micro and Nanoparticles for Biomedical Applications

ISBN-13: 9780323961387 / Angielski

Ranjita Shegokar; Eliana B. Souto

Opis

Characterization of Micro and Nanoparticles for Biomedical Applications is a helpful guide for industry researchers, academicians, regulatory experts and material scientists working in the field of pharmaceuticals, cosmeceuticals, nutraceuticals, agriculture, food, fragrance, and in the chemical industries. It aims to provide a one-stop resources on all the analytical techniques used in the field of micro and nanoparticles evaluation and characterization. The book's chapters bring together knowledge on current analytical methodologies, limitations and advances in the in vitro analysis field. Users from the equipment industry will benefit from its innovations by understanding the needs of researchers and the challenges of current techniques. With the expectation of "high-quality data" essentially dependent on the analytical methodology applied for characterization, this is integral to success. For routine products like tablets, capsules, and solutions, the regulatory guidelines, product-specific monographs, and pharmacopoeial annexures are set and "standard of operation." However, for nano-micro pharmaceuticals, regulatory guidelines are still evolving.

Spis treści

1. Particle size analysis 2. Zeta potential and surface characterization (eg, porosity, BET, hydrophilicity, etc.) 3. Microscopic analysis (AFM, SEM, TEM) etc. 4. XRD-EDS- crystallinity, compatibility 5. Isotonicity, osmolarity, osmolality, plasma/blood compatibility 6. In vitro release testing (including Franz diffusion cells) 7. Nanoparticle tracking analysis 8. Chemical analysis 9. Thermal analysis- DSC, TGA etc. 10. Chromatographic analyses (all) 11. Drug loading, entrapment assays of nano and micro particles: current practices 12. Nanoparticle dissolution 13. Sterility testing nanoparticles 14. Lyophilization characterization