Characterising the DNA Methylation Profile at a Neocentromere

ISBN-13: 9783838399317 / Angielski / Miękka / 2010 / 352 str.

Opis

This thesis was submitted as fulfilment of the requirements for a Doctor of Philosophy degree. This book chronicles the trials and tribulations of a Ph.D candidate undergoing research into centromere biology. Neocentromeres are a quirk of nature and arise after structural insult to a chromosome and are thought to contribute to the evolution of species. Neocentromeres are great models for centromere biology as the underlying DNA sequence is unique, unlike typical centromeres which are full of repetitive elements. Therefore, the goal of this thesis was to characterise and describe the role of DNA methylation in centromere biology.

O autorze

Nicholas Wong was born in Wellington, New Zealand where he obtained his Bachelor of Science with Honours at Victoria University of Wellington. Migrating to Melbourne, Australia, Nick then graduated with a Doctor of Philosophy at the University of Melbourne. Nick is currently a senior research officer at the Murdoch Childrens Research Institute.