Cerebrospinal Fluid Analysis in Multiple Sclerosis

ISBN-13: 9788847022072 / Angielski / Miękka / 2013 / 152 str.

Paolo Livrea;E. J. Thompson;Maria Trojano

Opis

In the spring of 1993 a meeting of the European Charcot Foundation was held in Bari as it was quite clear that there was a renaissance of Italian interest in cerebro- spinal fluid. Two of the influential figures with a long-standing commitment to this field were Professor Paolo Livrea and Dr. Maria Trojano. At this meeting we con- sidered the possibility of collecting together the various papers which had been presented, however the idea evolved further to the present volume, which incor- porates a broader view. This starts with the anatomical approach, including neuro- pathology, CSF cells and MRI correlations. It also includes virology, physiology of the blood-CSF barrier and the immunology of intrathecal responses. It further con- siders the relevance of the CSF parameters to therapy. Finally, the importance of quality assurance and handling of the precious fluid is discussed. The original plan was to have the book published in Italian, but we are grateful to the publishers for allowing English text, in order to have a wider, international audience. As is fate of any book, interest in this area has been accelerated considerably; nevertheless we hope this provides a summary from a multi-disciplinary point of view. From a pu- rely personal point of view, it certainly reflects the warmth of feeling which was evident at the meeting, and which led to the toast "Arrivederci, Bari". E. J.

Spis treści

Cerebrospinal fluid virological analysis in multiple sclerosis.- Neuropathology of multiple sclerosis lesions relevant to cerebrospinal fluid abnormalities.- The detection and significance of cerebrospinal fluid oligoclonal IgG.- The detection of IgA, IgM and free light chains abnormalities in cerebrospinal fluid.- Evaluation of blood cerebrospinal fluid barrier function and quantification of the humoral immune response within the central nervous system.- Lymphocyte subsets in multiple sclerosis cerebrospinal fluid.- Cerebrospinal fluid and serum soluble adhesion molecules in multiple sclerosis.- Cytokines in multiple sclerosis cerebrospinal fluid and serum.- Cerebrospinal fluid markers of demyelination: MBP and anti-brain protein antibodies.- Effects of immunotherapeutic strategies on cerebrospinal fluid parameters in multiple sclerosis.- Magnetic resonance imaging, proton magnetic resonance spectroscopy and cerebrospinal fluid abnormalities in multiple sclerosis.- Quality assurance and sampling handling in cerebrospinal fluid investigation.- Conclusions.