Cerebral Ischemia and Calcium

ISBN-13: 9783642858659 / Angielski / Miękka / 2012 / 586 str.

Alexander Hartmann; Wolfgang Kuschinsky

Opis

Although many books deal with isolated problems of calcium disturbance in relation to cardiac and cerebral function, this is the first to focus specifically on calcium metabolism and cerebral ischemia. Internationally acknowledged experts present recent data and new concepts in an interdisciplinary approach to the subject. They examine basic information on the pathophysiology of cellular events, the damage caused by excitotoxic substances, and the effects of calcium antagonistic drugs as measured in experimental animals. These contributions may help lead to possible therapeutic interference for the prevention of calcium imbalance.

Spis treści

Pharmacology of Calcium and Cerebral Ischemia.- Academic Hemianopia and the Treatment of Cerebrovascular Disease.- The Classification of Calcium Antagonists (With 4 Figures).- Pharmacological Activities of Calcium Antagonists: Therapeutic Applications and Adverse Reactions (With 3 Figures).- Cellular Movements and Distribution of Calcium (With 3 Figures).- Cerebral Ischemia: Pathophysiology and Biochemistry.- New Methods for Topographical Imaging of Physiologically Defined Boundary Zones in Focal Cerebral Ischemia (With 2 Figures).- Experimental Hypoglycemia: Correlation Between EEG Abnormalities and Structural Alterations (With 3 Figures).- Blood-Brain Barrier Permeability to Micromolecules After Focal Cerebral Ischemia (With 3 Figures).- Mediation of Platelet and Coagulation Events by Blood Flow: Basic Mechanisms of Thrombosis in Cerebral Ischemia (With 3 Figures).- Altered Cerebral Collaterals and Protection from Infarction (With 3 Figures).- Physical Activity Determines Survival of Mongolian Gerbils from Forebrain Ischemia (With 1 Figure).- Immunocytochemical Studies on Some Brain Regions in a Rat Model of Incomplete Cerebral Ischemia. Relationship to Behavior and Aging (With 3 Figures).- Effects of Transient Global Cerebral Ischemia on Peptide Neuronal Populations in Different Brain Regions and on Behavioral Performances in Rats (With 3 Figures).- Related Responses Between Dopamine Synapses and Astrocytes in the Rat Striatum After Global Cerebral Ischemia: A Morphometric and Microdensitometric Study (With 3 Figures).- The Effects of Transient and Long-Term Ischemia on Tissue PO2 in the Brain Cortex (With 5 Figures).- Vasomotor Response and Blood-Brain Barrier Function of Rat Brain Studied in a Closed Cranial Window Preparation (With 2 Figures).- Regional Cerebral Blood Flow After Cryoinjury of the Rabbit Brain.- Experimental Cerebral Ischemia and Calcium.- Calcium Antagonists in Brain Ischemia — Experimental Observations (With 1 Figure).- In Vivo Fluorometric Measurement of Changes in Cytosolic Free Calcium from the Cat Cortex During Anoxia, Ischemia, and Postischemic Reperfusion (With 3 Figures).- Calcium Antagonists and a Rapid Shift of Water from Extracellular to Intracellular Space After Cerebral Ischemia (With 2 Figures).- A Fluorometric Technique for the In Vivo Measurement of Intracellular Calcium (With 3 Figures).- Calcium Movements in Brain During Failure of Energy Metabolism (With 2 Figures).- Glutamate Antagonism as a Pharmacological Approach to Prevent Calcium Influx in Focal Cerebral Ischemia.- Calcium Antagonists and Experimental Focal Cerebral Ischemia (With 4 Figures).- Effect of Calcium Antagonists on Cerebral Blood Flow, Protein Synthesis, and Histopathology After Global Ischemia of Gerbil Brain (With 3 Figures).- The Effects of a Dihydropyridine Calcium Antagonist on Cerebral Blood Flow with and without Middle Cerebral Artery Occlusion (With 5 Figures).- Nimodipine Binding in Cerebral Ischemia (With 1 Figure).- Calcium Overload and Brain Damage in Stroke-Prone Spontaneously Hypertensive Rats: Prevention by Nimodipine and by Parathyroidectomy (With 2 Figures).- Neurotransmitters and Calcium During Hypoxia (With 1 Figure).- Protective Effects of Calcium Antagonists Against Brain Damage Caused by Ischemia (With 3 Figures).- Ultrastructural Calcium Cytochemistry in the Study of Ischemic Brain Injury (With 3 Figures).- Roles of Calcium-Activated Enzymic Reactions in Ischemia-Induced Neuronal Injury (With 3 Figures).- The Effects of Experimental Anoxia on Glycolysis, Energy Status, Cytosolic Free Calcium, and Glutamate Release from Isolated Nerve Terminals (With 3 Figures).- Ionized Free Calcium Concentration and Deformability in Platelets (With 5 Figures).- Calcium 45 Accumulation in the Dentate Hilus: Possible Effect of NMDA Receptor Blockers (With 3 Figures).- Vascular and Direct Effects on Cerebral Energy Metabolism of Emopamil (With 3 Figures).- Cytoprotective Characteristics of Dihydropyridine Calcium Antagonists in a Rat Model of Stroke: Implications for Clinical Trials (With 4 Figures).- Effect of Diltiazem on the Cortical Microcirculation in Acutely Produced Cerebral Ischemia in Cats (With 2 Figures).- Comparison of the Effects of Flunarizine and Nimodipine on Cerebral and Temporal Arteries with Comments on Their Clinical Use in Cerebrovascular Disorders (With 1 Figure).- The Effect of Calcium Antagonists in Experimental Atherosclerosis, the Underlying Cause of Heart and Cerebral Vascular Diseases (With 3 Figures).- Thrombosis on Stenosis: Mechanisms of Thrombus Growth and Embolization on Carotid Atherosclerotic Plaques (With 3 Figures).- Suppression of Brain and Adrenal Gland Arteriosclerosis by Calcium Antagonism in Hypertensive Rats (Skelton Hypertension) (With 3 Figures).- Extracellular Ion Activities During Ischemia and Reperfusion of the Rat Brain: Influences of Drugs (With 3 Figures).- Clinical Cerebral Ischemia and Calcium.- Density of Functioning Cerebral Capillaries in Stroke Patients, Determined by PET (With 3 Figures).- Nimodipine Clinical Trial in Acute Ischemic Stroke (With 1 Figure).- Nimodipine in Acute Ischemia Stroke: A Controlled Trial.- Calcium Blocker Therapy in Acute Ischemic Stroke.- A Pilot Study of Nicardipine for Acute Ischemic Stroke. The Nicardipine Study Group (With 3 Figures).- An Open Study with Intravenous Application of Flunarizine in Acute Stroke (With 2 Figures).- CBF Decreases in Ischemic Areas After Calcium Antagonist Treatment in Acute Stroke.- The Effect of Nimodipine on ICP and CBF in the Awake Patient (With 3 Figures).- Migraine.- Calcium Entry Blockers in Migraine: The State of the Art (With 2 Figures).- Nimodipine, a Calcium Entry Blocker, Platelets, and Migraine.- Treatment of Acute Migraine Attacks with Intravenous Flunarizine (With 3 Figures).- Treatment of Migraine and Cluster Headache with Calcium Antagonists (With 2 Figures).- Calcium Entry Blockers in Migraine Prophylaxis — A Critical Review of Therapeutic Trials (With 1 Figure).- Epilepsy.- Calcium, Neuronal Hyperexcitability, and Ischemic Neuronal Injury (With 3 Figures).- Calcium Accumulation in Ischemia and Seizures: Cause or Result of Cell Death? (With 4 Figures).- Aspects of Calcium Ions in Cortical Spreading Depression (With 4 Figures).- Depression of Focal and Generalized Tonic-Clonic Epileptic Activity by the Organic Calcium Antagonist Verapamil (With 2 Figures).- Flunarizine, a Useful Adjuvant for Therapy-Resistant Epilepsy Patients.- Review of Flunarizine in Epilepsy.- Brain Protection.- The Effects of Flunarizine on Survival Following Prolonged Cerebral Ischemia in the Gerbil (With 4 Figures).- Cerebroprotective Effects of a Parenteral Flunarizine Formulation (With 3 Figures).- Studies on the Efficacy and Mechanism of Action of a Calcium Blocker After Global Ischemia (With 3 Figures).- Calcium Antagonists in Acute Cerebral Damage: Therapy or Risk for the Brain? (With 3 Figures).- Subarachnoid Hemorrhage.- Calcium Channel Blockade in Cerebral Vasospasm.- Cerebral Ischemia Following Subarachnoid Hemorrhage — The Efficacy of Nimodipine as Therapy (With 22 Figures).- Treatment of Symptomatic Cerebral Vasospasm After Subarachnoid Hemorrhage by Intraarterial Perfusion with Nimodipine (With 5 Figures).- Effect of Nimodipine on CO2 Reactivity of Patients with Normal and Spastic Basal Cerebral Arteries: A Transcranial Doppler Ultrasound Study (With 4 Figures).- Treatment of Subarachnoid Hemorrhage with Oral Nimodipine: Preliminary Report of the British Aneurysm Trial.- Various.- Impaired Calcium Homeostasis and Calcium Antagonists in Muscle Diseases.

O autorze

Alexander Hartmann, geboren 1985, ist einer der erfolgreichsten Mentalisten Europas und Deutschlands jüngster Top100 Keynote-Speaker. Seinen großen Durchbruch schaffte er in der Pro7 Sendung "The next Uri Geller". Inzwischen hat er seine eigene TV-Show, hält regelmäßig Vorträge und Seminare, hat ein eigenes Hypnosezentrum gegründet und sich als Experte für das Thema Unterbewusstsein etabliert. Der deutsch-englische Muttersprachler ist mit seinen Seminaren und Vorträgen auch international sehr gefragt. Er lebt und arbeitet in Stuttgart.