Cerebral Blood Flow: Mechanisms of Ischemia, Diagnosis, and Therapy

ISBN-13: 9783540426844 / Angielski / Miękka / 2002 / 312 str.

Michael R. Pinsky; M. R. Pinsky

Opis

Covering the most important aspects of cerebral blood flow (CBF) from bench to bedside, this volume first defines the basic physiology of CBF: those qualities that make it unique or are shared with other organs and their clinical implications. There follows a section on CBF pathophysiology that explores many of the known and proposed mechanisms of cerebral ischemia in stroke and trauma states. The third section describes the numerous and powerful means available to measure blood flow, tissue function and overall perfusion. These areessential measures if one is to assess the effectiveness of therapies aimed at preventing or reversing cerebral ischemia. The final section describes the interesting and often successful clinical trials aimed at preventing or reversing cerebral ischemia.

Spis treści

Section 1. Physiology and Pathophysiology.- 1. History of Cerebral Blood Flow Assessment.- 2. Neural Regulation of the Cerebral Circulation.- 3. Role of Endothelium in Regulation of the Brain Microcirculation.- 4. Molecular Pathogenetics of Cerebral Aneurysms: Current Concepts and Future Directions.- Section 2. Ischemic Brain Injury.- 5. Triggering Events in Ischemic Brain Injury.- 6. Ischemic Mechanisms in Traumatic Brain Injury.- 7. Coupling and Compartmentation of Cerebral Blood Flow and Metabolism.- 8. The Genetic Control of Ischemic Neuronal Cell Death.- 9. Cerebral Resuscitation from Temporary Complete Global Brain Ischemia.- 10. The Ischemic Penumbra: Pathophysiology and Therapeutic Implications.- Section 3. Assessment of Cerebral Blood Flow.- 11. The Assessment of Determinants of Cerebral Oxygenation and Microcirculation.- 12. Computed Tomography, Angiography, and Perfusion Imaging of Acute Stroke.- 13. The Use of Xenon/CT Cerebral Blood Flow Studies in Acute Stroke.- 14. Advances in Imaging in Ischemic Stroke.- 15. Assessment of Cerebrovascular Pathophysiology.- 16. Cerebral Blood Flow Measurement with Positron Emission Tomography.- Section 4. Current Status of Clinical Trials in Acute Stroke.- 17. Thrombolysis for Acute Stroke.- 18. Neuroprotective Stroke Trials: A Ten Year Dry Season.- 19. Interventional Neuroradiology in Acute Ischemic Stroke: Extracranial and Intracranial Angioplasty and Stenting.- 20. Therapeutic Moderate Hypothermia and Fever.- 21. Cerebral Hemodynamics and Stroke Risk in Patients with Complete Carotid Artery Occlusion. Is There a Role for Cerebral Revascularization?.