Central Nervous System: Studies on Metabolic Regulation and Function

ISBN-13: 9783642657160 / Angielski / Miękka / 2011 / 252 str.

E. Genazzani; H. Herken

Opis

This book is based on the Symposium "Metabolic Regulation and Functional Activity in the Central Nervous System" which was held on September 16 and 17, 1972, at Saint Vincent (Aosta)/Italy, and was sponsored by the Accademia di Medicina di Torino with the scientific cooperation of the Istituto di Farmacologia, Universita di Torino, and the Pharmakologisches Institut der Freien Universitat Berlin. Its purpose was to give a greater number of scientists from different countries an opportunity to report their latest results under a heading concerning general relationships between metabolism and function. We quite deliberately refrained from pursuing the partly heterogenous subjects into details. Thus, the organizers hoped to be able to interest a greater circle of readers for the manifold subjects from various fields dealing with the investigation of metabolic processes in the central nervous system. The discussion remarks to the lectures could not be considered for printing. The Accademia di Medicina di Torino and all others concerned do not only thank Dr. R. Di Carlo and other members of the Istituto di Farmacologia, Universita di Torino, for the excellent work they performed in preparing this Symposium, but also the Amministrazione Regionale della Valle di Aosta and SIT A V di Saint-Vincent for their generous support and their kind hospitality which made the stay at Saint-Vincent most agreeable for all participants."

Spis treści

I. Biochemical Analysis of Metabolic Pathways.- Adenosine in Neurohumoral and Regulatory Roles in the Brain.- Lipid Metabolism and its Regulation in Brain Tissue.- Choline and its Metabolic Successors in Brain.- Structural and Functional Significance of Brain Glycoproteins.- Antimetabolic Action on the Pentose Phosphate Pathway in the Central Nervous System Induced by 6-Aminonicotinamide.- Studies of Flux Rates at the Glucose 6-Phosphate Crossover.- Purification and Regulation of Phosphate-Activated Pig Brain Glutaminase.- Functional Aspects of Nucleic Acid Metabolism in Brain.- Uptake and Action of Glycine in Cultures of Central Nervous Tissue from Rat.- Neuronal Activity and Axonal Flow.- Intra-Axonal Transport of Young Amine Granules: Implications for Nerve-Terminal Function.- The Application of Micromethods to Neurochemistry.- Serum as Medium for Brain and Other Tissues Respiring in vitro.- II. Membrane Function and Neurotransmission.- Importance of Structure and Organization for the Chemical Reactions in Excitable Membranes.- Allostery and Permeability of Cellular Membranes.- Release of 3H-Acetylcholine and 3H-Choline from the Cerebral Cortex of the Rat Following Administration of 3H-Choline.- Changes in the Enzymes for the Metabolism of Acetylcholine During Development of the Central Nervous System.- Acetylcholinesterase and Choline Acetyltransferase in Hippocampus after Various Septal Lesions in Rats.- Subcellular Localization of Glycosyl-Transferases in Synaptosomes and Mitodrondria of Brain.- Neurochemical Aspects of Behavior.- Histamine in the Brain: Importance of Transmethylation Processes and Their Regulation.- Macromolecular Organization of Membranes and Organelles in Nerve Tissue.- III. Hormonal and Pharmacological Studies.- Effects of Ergot DH-Alkaloids on the Metabolism and Function of the Brain. An Approach Based on Studies with DH-Ergonine.- Effect of Nicergoline on Some Ischemia-Induced Metabolic Changes in the Brain of Cat.- Interference of Neurologically Active Drugs with Metabolism of RNA in Brain.- Some Histochemical, Biochemical, and Pharmacological Aspects of Differentiation of Neuroblastoma Cells of Mouse.- Analogues of ACTH, Conditioned Avoidance Behaviour and Metabolism of Macromolecules in Brain of Rat.- Hypophysectomy and Metabolism of Brain Proteins.- Early Effects of Thyroxine and Reserpine on the Hypothalamic-Pituitary-Thyroid Axis of Young Rats.