Central Nervous System Metastasis, the Biological Basis and Clinical Considerations

ISBN-13: 9789400752900 / Angielski / Twarda / 2012 / 228 str.

Diane Palmieri

Opis

Here is a thorough survey of the biology and treatment of CNS metastasis, including natural history, risk factors, molecular biology, the blood-brain barrier, imaging, quality of life, surgery, chemotherapy, radiation and the future of targeted therapies.

Recenzje

From the reviews:
"This book reviews both the biology of central nervous system metastases and the basics of diagnosis and management. ... The audience for this book is broad, in that it may attract both basic scientists and the clinicians. ... the book is well written and easy to understand. ... This is a book that I would value in my personal library. ... I have not seen a book in this field with a similar breadth in covering both a scientific and clinical overview of CNS metastases." (Priya U. Kumthekar, Doody's Book Reviews, July, 2013)

Spis treści

Preface.- List of Contributors.- 1 An Introduction to Brain Metastasis.- 2 The Molecular Biology of Brain Metastasis.- 3 The Brain Microenvironment.- 4 Vascular permeability within brain metastases.- 5 Imaging Experimental Brain Metastases.- 6 Possibilities of Targeted Therapies for Brain Metastasis.- 7  Surgery for Brain Metastasis.- 8  Is There A Role for Systemic Chemotherapy in the Treatment of Brain Metastases?.- 9  Radiation Therapy of CNS Metastases.- 10  Leptomeningeal Metastasis.- 11 Quality of Life in CNS Metastasis.- Index.

Blurb

This volume covers what is known regarding the natural history, basic biology, and clinical aspects, including imaging and treatment, of CNS metastasis. Three chapters cover the biology of the brain and brain metastases: molecular biology, includes what is known about specific genes/proteins involved in the process of metastasis and model systems to study brain metastasis; brain microenvironment, focuses on the resident cells of the microenvironment and their role in CNS metastasis; and the blood-brain barrier, includes a discussion of permeability with respect to brain metastases. A discussion of experimental imaging covers both the biology of brain metastasis from an imaging perspective and the use of imaging techniques to study brain metastases. The three clinical chapters discuss treatment options of surgery, chemotherapy, and radiation. The potential for novel targeted therapies is also addressed. Because of the uniqueness of the disease, leptomeningeal metastasis is discussed separately. The last chapter is devoted to quality of life issues associated with CNS metastasis.