Cellular and Molecular Biology of Mammary Cancer

ISBN-13: 9781461282570 / Angielski / Miękka / 2011 / 528 str.

E. Anderson; G. Heppner; W. Kidwell

Opis

The idea for this book arose during the 1985 Gordon Conference on "Mammary Gland Biology." New developments in the methodology of cell biology and the explosive growth of molecular biology had begun to impact upon our understanding of mammary gland growth and function. It seemed a propitious time for summarizing the current status of knowledge of the cell and molecular biology of mammary cancer and for attempting to outline future areas of concern and interest. The reviews presented here were completed by the Fall of 1986. Although new insights will surely continue to emerge, it is hoped that the material in this volume will form not only a current update but a basic core of information for future experiments. We have not attempted to cover all areas of mammary gland transformation. Those areas where recent detailed reviews are already available have been omitted. Also, the areas of normal gland development, cell ultrastructure, hormone responsiveness, chemotherapy and clinical aspects of mammary cancer have not been included. Instead, we have selected those areas where the development of new methodology, reagents and results have led to new ideas about mammary gland function and development as they are related to neoplasia.

Spis treści

Mammary Epithelial Markers and Cell Lineages of Mammary Neoplasia.- Changes in Antigen Patterns During Development of the Mouse Mammary Gland: Implications for Tumorigenesis.- Stem Cells in Mammary Development and Cancer.- Structural Components as Markers of Differentiation and Neoplastic Progression in Mammary Epithelial Cells.- Chromosomes in Breast Cancer.- Extra cellular Matrix and Cell-Cell Interaction.- Epithelium — Mesenchyme Interaction in the Fetal Mammary Gland.- Extracellular Matrix Effects on Mammary Cell Behavior.- Extracellular Matrix: Structure, Biosynthesis, and Role in Mammary Differentiation.- Adipocyte, Preadipocyte and Mammary Epithelial Cell Interaction.- Interaction of Mammary Tumor Subpopulations.- Hormones and Growth Factors.- Rodent Models to Examine In Vivo Hormonal Regulation of Mammary Gland Tumorigenesis.- Primary Culture Systems for Mammary Biology Studies.- Prolactin Effects and Regulation of its Receptors in Human Mammary Tumor Cells.- Regulation of Growth and Secretion of Growth Factors by 17 Beta-Estradiol and V-RASH Oncogene in Human Mammary Cell Lines.- Growth Factor Production by Mammary Tumor Cells.- Prostaglandins in Breast Cancer.- MMTV and Gene Expression.- Exogenous and Endogenous Mouse Mammary Tumor Viruses: Replication and Cell Transformation.- On the Mechanism of Carcinogenesis by Mouse Mammary Tumor Virus.- Hormonal Control of Mouse Mammary Tumor Virus Transcription.- Overt and Cryptic Functions of the Mouse Mammary Tumor Virus Long Terminal Repeat DNA Sequence.- Transformation.- Cell Biology of Mouse Mammary Carcinogenesis in Organ Culture.- Involvement of Oncogenes in Carcinogenesis.- Role of Differentiation on Transformation of Human Breast Epithelial Cells.- Growth and Transformation of Human Mammary Epithelial Cells in Culture.- Cellular Manifestations of Human Breast Cancer.- Cytokinetics of Mammary Tumor Models and the Effect of Therapeutic Intervention.- Current Concepts of Selenium and Mammary Tumorigenesis.- Dietary Retinoids and the Chemoprevention of Mammary Gland Tumorigenesis.