Cellular and Molecular Approaches to Regeneration and Repair

ISBN-13: 9783319666785 / Angielski / Twarda / 2017 / 541 str.

Paul A. Lapchak; John H. Zhang

Opis

This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery.

Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential.

Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke.

Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.

Spis treści

Introduction: The Future of Neuroprotection and Regeneration For Stroke (Paul A. Lapchak, Ph.D., Cedars-Sinai Medical Center, Department of Neurology & Neurosurgery, Los Angeles, CA; Paul.lapchak@cshs.org)

Section 1: Stem cells

Chapter: Stem cell bio-bridging for stroke (Cesario Borlongan; Univ South Florida, Florida, USA: cborlong@health.usf.edu)

Chapter: Stem cell technology (Pascal GERVOIS; Univ Hasselt, Belgium: pascal.gervois@uhasselt.be)

Ling Wei, Shanping Yu, Emory University

Li-Ru Zhao, upstate New York

Aizman/Andrews-Zwilling/Steinberg SanBio Inc. California

Section 2: Exosomes

Chapter: Exosomes for stroke (Zhang, Zhenggang; Henry Ford, Detroit, MI; ZZHANG1@hfhs.org)

Zhi Di, Frank Sharp, UC-Davis

Kejie Ying, U Pittsburgh

Section 3: miRNA's

Chapter: Neuroprotective miRNA's for Ischemic stroke (Dr. Jingli Liu, The First Affiliated Hospital, Guangxi Medical University, China; lilicomet@163.com)

Raghu Vemuganti, U Wisconsin 

Jun Chen, U Pittsburgh

Section 4: Trophic factors and molecular mimics

Chapter: Polyphenols and trophic factor mechanisms. (Dr. Fernanda Borges, Portugal; fborges@fc.up.pt)

Jieli Chen, Henry Ford Hospital

Miguel Perez-Pinzon, U Miami

Chapter: Designer Curcumin molecules: Neuroprotection and Neuroplasticity. (Paul A. Lapchak, Ph.D., Cedars-Sinai Medical Center, Department of Neurology & Neurosurgery,

Los Angeles, CA;

Paul.lapchak@cshs.org)

Section 5: Clinical trials

David Libeskind, UCLA

Gary Steinberg Stanford

Blurb

This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery.

Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to understand the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential.

Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke.

Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.