Cellular and Biochemical Mechanisms of Obesity

ISBN-13: 9783030847654 / Angielski / Miękka / 2022 / 414 str.

Paramjit S. Tappia; Bram Ramjiawan; Naranjan S. Dhalla

Opis

Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood.

Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). 

This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.   

Spis treści

A. INTRODUCTION

Paramjit S. Tappia, Bram Ramjiawan, Naranjan S. Dhalla

Asper Clinical Research Institute, St. Boniface Hospital

CR3129-369 Tache Avenue

Winnipeg, Manitoba, Canada R2H 2A6

Email: ptappia@sbrc.ca

Title: Cellular and biochemical mechanisms of obesity

B. Inflammation/cytokines

1. Oreste Gualillo

SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Building C, Travesía da Choupana S/N, Santiago de Compostela 15706, Spain.

Email: oreste.gualillo@sergas.es

Title: The role of inflammation in obesity

2. Kyoungho Suk

Department of Pharmacology, Brain Science & Engineering Institute, Department of Biomedical Science, BK21 PLUS KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

Email: ksuk@knu.ac.kr

Title: Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity

3. Jennifer M. Monk

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada

Email: jmonk02@uoguelph.ca

Title: The role of the inflammasome in obesity

4. Geert van Loo

VIB Center for Inflammation Research, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.

Email: geert.vanloo@irc.vib-ugent.be

Title: Adipose tissue macrophages and their polarization in health and obesity

5. Sonia Caprio

Department of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut.

Email: sonia.caprio@yale.edu

Title: Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation

6. Giulia Maurizi

Clinica di Ematologia, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.

Email: g.maurizi@univpm.it

Title: The interplay between adipocytes and immune system cells in the pathophysiology of obesity

C. Hormonal imbalances

1. Agatha A. van der Klaauw

Department of Clinical Biochemistry, Metabolic Research Laboratories - Institute of Metabolic Science, University of Cambridge, Cambridge, England.

Email: av330@medschl.cam.ac.uk

Title: Neuropeptides in Obesity and Metabolic Disease

2. Heather Roff, Colette Jappy

Donor Network West, 12667 Alcosta Boulevard #500, San Ramon, CA 94583; Kaiser Permanente, Redwood City, CA.

Email: Hroff11@gmail.com; colette.jappy@gmail.com

Title: Adiposity and the Role of Neuroendocrine Hormones in Energy Balance

3. Jarosław Kozakowski

Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, 80 Cegłowska St., 01-809 Warsaw, Poland

Email: jkozakowski@cmkp.edu.pl

Title: Obesity in menopause

4. Brigitte Leeners

Division of Reproductive Endocrinology, University Hospital Zurich, Frauenklinikstr. 10, CH 8091 Zurich, Switzerland. Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland.

Email: Brigitte.Leeners@usz.ch

Title: Ovarian hormones and obesity

5. Shiying Shao

Division of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, P.R. China.

Email: shaoshiying@hotmail.com

Title: The role of tissue-specific glucocorticoids in central obesity

6. D. do Nascimento Marreiro

665 Ed. Palazzo Reale, Hugo Napoleão St. apt 2001 Jóquei Teresina, Piauí

Brazil 64048320.

Email: dilina.marreiro@gmail.com

Title: Thyroid function in obesity

7. Terry Hinds

Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine, Toledo, Ohio.

Email: Terry.Hinds@utoledo.edu

Title: Glucocorticoid hormones: cause or cure for obesity

8. Asit Ranjan Ghosh

Centre for Infectious Diseases and Control, School of BioSciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.

Email: asitranjanghosh@vit.ac.in

Title: Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota

9. Anna Gavrieli

Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Stoneman 820, Boston, MA 02215.

Email: agavriel@bidmc.harvard.edu

Title: Recent advances in leptin and obesity

10. James R. Sowers

Burns, Diabetes and Cardiovascular Center, University of Missouri, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA.

Email: sowersj@health.missouri.edu

Title: Pathophysiology of obesity due to neurohormonal dysregulation and autophagy

D. Autonomic nervous system

1. Rosa Maria Bruno

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Email: rosamaria.bruno@unipi.it

Title: The Role of the Autonomic Nervous System in the Pathophysiology of Obesity

2. Hideki Katagiri

Division of Advanced Therapeutics for Metabolic Diseases, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Email: katagiri@mail.tains.tohoku.ac.jp

Title: Disturbance of neuronal signals in the pathophysiology of obesity

3. Ana I. Domingos

Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Email: dominan@igc.gulbenkian.pt

Title: The sympathetic neuro-adipose connection and the control of body weight

4. Gino Saravalle

Cardiology Department, S. Luca Hospital, Istituto Auxologico Italiano, Piazza Brescia 20, 20149, Milan, Italy.

Email: g_seravalle@yahoo.com

Title: Sympathetic activation in obesity

5 Zhengtang Qi, Shuzhe Ding

College of Physical Education and Health, East China Normal University, 500 Dongchuan Road, 200241 Shanghai, P.R. China,

Email: qzht79@163.com

Title: Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism

6. Markus P. Schlaich

Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.

Email: markus.schlaich@uwa.edu.au

Title: Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome

7. Elisabeth A. Lambert

Baker IDI Heart & Diabetes Inst., PO Box 6492, St. Kilda Rd. Central, Melbourne, Victoria, 8008, Australia.

Email: elisabeth.lambert@bakeridi.edu.au

Title: Should the sympathetic nervous system be a target to improve obesity?

E. Oxidative stress

1. Alice Carrier

CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix Marseille University , Marseille, France.

Email: alice.carrier@inserm.fr

Title: Metabolic Syndrome and Oxidative Stress: A Complex Relationship

2. Sushil K. Jain

Department of Pediatrics, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103,

Email: sjain@lsuhsc.edu

Title: The role of oxidative stress in the pathogenesis of obesity

3. Ashok K. Grover

Department of Medicine, HSC 4N41, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1. Canada.

Email: groverak@mcmaster.ca

Title: How effective are antioxidant supplements in obesity

4. Lucia Marseglia

Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.

Email: lmarseglia@unime.it

Title: Oxidative stress in obesity: a critical component in human diseases

5. Norma L. Gomez-Viquez

Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados- Instituto Politécnico Nacional, Mexico City, Mexico.

Email: letyviquez@hotmail.com

Title: Cellular mechanisms involved in the pathophysiology of obesity during oxidative stress

6. Ramaroson Andriantsitohaina

Department of Biochemistry, Université d'Angers, CHU Angers, 4 rue Larrey, 49933 Angers Cedex 9, France.

Email: ramaroson.andriantsitohaina@univ-angers.fr

Title: Oxidative stress and metabolic pathologies: from an adipocentric point of view

7. Dominique Bonnefont-Rousselot

Service de Biochimie Metabolique, Groupe hospitalier Pitie-Salpetriere (Assistance Publique - Hopitaux de Paris), 47-83 boulevard de l'Hopital, 75651 Paris Cedex 13, France.

Email: dominique.rousselot@psl.aphp.fr

Title: Oxidative stress contributes to the pathogenesis of obesity

8. Concepcion M. Aguilera

Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre for Biomedical Research, University of Granada, 18100 Armilla, Granada, Spain.

Email: caguiler@ugr.es

Title: The genetics of oxidative stress in obesity

9. Morihiro Matsuda

Institute of Clinical Research, National Hospital Organization, Kure Medical Center, and Chugoku Cancer Center, Hiroshima, Japan.

Email: morihiro-m@kure-nh.go.jp

Title: Increased oxidative stress is associated with adipocyte fat accumulation

10. Atilla Engin

Faculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey.

Email: dr.aengin@gmail.com

Title: The vicious cycle of oxidative stress and obesity

F. Signal Transduction/sensors and regulators of metabolic status

1. Thue W. Schwartz

Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, Laboratory for Molecular Pharmacology, Department for Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

Email: tws@sund.ku.dk

Title: GPCR-Mediated Signaling of Metabolites in the pathophysiology of obesity

2. Laura Herrero

Department of Biochemistry and Physiology, School of Pharmacy, Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain.

Email: lherrero@ub.edu

Title: Ceramide signaling in obesity

3. Kalyana.Nandipati

Department of Surgery, Creighton University School of Medicine, 601 N. 30th Street, Suite # 3700, Omaha, NE, 68131, USA.

Email: Kalyana.Nandipati@alegent.org

Title: The role of the triggering receptor in the pathophysiology of obesity

4. Pedro Bullon

Department of Oral Medicine and Periodontology, Dental School, University of Seville,

C/Avicena s/n, Seville, 41009, Spain.

Email: pbullon@us.es

Title: The AMPK pathway in the development of obesity

5. Andrew Murphy

Haematopoiesis and Leukocyte Biology, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, 3004, Australia.

Email: andrew.murphy@bakeridi.edu.au

Title: Interleukin-1 superfamily: Divergent roles in obesity

6. Y.-X. Tao

Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.

Email: taoyaxi@auburn.edu

Title: Ghrelin Receptor Mutations and Human Obesity

Jongsook Kim Kemper

University of Illinois at Urbana-Champaign, Urbana, IL, United States.

Email: jongsook@illinois.edu

Title: Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism

8. Daniel J. Gough

Hudson Institute of Medical Research, 27‐31 Wright Street, Clayton, Victoria 3168, Australia.

Email: daniel.gough@hudson.org.au

Title: JAK/STAT signaling pathway in the development of obesity

9. Long T. Nguyen

Kolling Institute, Level 9, Royal North Shore Hospital, St. Leonard, NSW 2065, Australia.

Email: lngu8923@uni.sydney.edu.au

Title: SIRT1 and SIRT3 as mediators for the development of obesity

10. Tsutomu Sasaki

Laboratory for Metabolic Signaling, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, Japan.

Email: tsutomus@gunma-u.ac.jp

Title: Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

11. Peter Arner

Lipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, SE-141 86 Stockholm, Sweden.

Email: peter.arner@ki.se

Title: Interplay between Obesity and cGMP Signaling in adipose tissue