Cellular Respiration and Carcinogenesis

ISBN-13: 9781934115077 / Angielski / Twarda / 2008 / 195 str.

Shireesh P. Apte; Shireesh Apte; Rangaprasad Sarangarajan

Opis

Cellular Respiration and Carcinogenesis presents leading experts in the field as it informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with, and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation (cellular respiration) to normally burn fuel to generate energy, vis-a-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse to a cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development."

Recenzje

From the reviews:

"It includes 12 chapters on topics ranging from the regulation of glucose metabolism in neoplastic cells ... . The book is written for clinical and basic science researchers across a wide range of life science disciplines ... . Students and experts ... will appreciate this thoughtful and stimulating review of the field. ... This book captures the excitement of the field. This is the book to have if you are interested in glucose metabolism, oxygen utilization, ATP, mitochondrial function, apoptosis, and cancer." (Bruce A. Fenderson, Doody's Review Service, May, 2009)

Spis treści

Oxidative Phosphorylation and Cancer: The Ongoing Warburg Hypothesis.- The Electron Transport Chain and Carcinogenesis.- Respiratory Control of Redox Signaling and Cancer.- Cellular Respiration and Dedifferentiation.- Cellular Adaptations to Oxidative Phosphorylation Defects in Cancer.- Regulation of Glucose and Energy Metabolism in Cancer Cells by Hypoxia Inducible Factor 1.- The Role of Glycolysis in Cellular Immortalization.- Metabolic Modulation of Carcinogenesis.- Mitochondrial DNA Mutations in Tumors.- Cellular Respiration and Tumor Suppressor Genes.- Uncoupling Cellular Respiration: A Link to Cancer Cell Metabolism and Immune Privilege.- How Cancer Cells Escape Death.

Blurb

Cellular Respiration and Carcinogenesis informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text by leading experts in the field, offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanisms or pathways of cellular respiration; oxidative phosphorylation and glycolysis.  The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse of cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development.

 

 

About the Editors:

Shireesh P.Apte, Ph.D has 10+ years experience in the pharmaceutical industry researching and formulating anti-cancer drugs. He holds one US patent and has 10+ related publications. He is a member of the US Pharmacopoeia excipients expert committee.

Rangaprasad Sarangarajan, Ph.D. has over 10 years of research experience in an academic setting with extensive publications in areas of pharmacology & toxicology with focus on cancer treatment.  He is active member of various professional organizations including the Society of Toxicology, American Society for Pharmacology & Toxicology and Pan American Society for Pigment Cell Research.