Cellular Ageing and Replicative Senescence

ISBN-13: 9783319262376 / Angielski / Twarda / 2016 / 364 str.

Suresh Rattan; Leonard Hayflick

Opis

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology.
Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Spis treści

Preface

Section I History and origins
Chapter 1: Origins of the Hayflick system, the phenomenon and the limit. (an interview by Suresh I.S. Rattan)

Chapter 2:  Experimental foundations of the Hayflick system. (an interview by Suresh I.S. Rattan)

Section II Serial passaging and progressive changes
Chapter 3: Slowing down of the cell cycle during fibroblast proliferation. by: Alvaro Macieira-Coelho

Chapter 4: Influence of donor age and species longevity on replicative cellular senescence. by: Lorenzini and Andrea B. Maier

Chapter 5: Ageing of the stem cells: the conjoined twosome growing old –stem cell and its niche. by: Günter Lepperdinger

Chapter 6: Ageing and senescence in immune cells in vitro and in vivo. by: Graham Pawelec and Yvonne Barnett

Chapter 7: Telomere shortening – a mere replicometer? by: Stella Victorelli and Joao Passos

Chapter 8: Modelling cellular ageing: mathematical and computational approaches. by: Tarynn M. Witten

Section III AGEING, CANCER and sen

escence
Chap

ter 9: Cell cycle checkpoints and senescence. by: Renu Wadhwa, Zeenia Kaul and Sunil C. Kaul

Chapter 10: Mitochondrial reactive oxygen species in cellular senescence. by: Timothy Nacarelli, Claudio Torres and Christian Sell

Chapter 11: Cellular aging and tumour regulation. by: Andreas Simm, Barbara Seliger and Lars-Oliver Klotz

Chapter 12:

Biomarkers of replicative senescence revisited. by: Jan Nehlin

Section IV  AGEING ModulatORS
Chapter 13: Stress-induced (premature) senescence. by: Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire and Olivier Toussaint

Chapter 14: Implications of cellular senescence on aging and disease in the brain. by:

Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D’Agostino, Christian Sell and Claudio Torres

Chapter 15: Small non coding RNAs in senescence and aging. by: Joseph Dhahbi

Chapter 16: Targeting senescent cells to improve huan health by: Tobias Wijshake and Jan M. A. van Deursen

Section V  RECAPITULATION AND FUTURE EXPECTATIONS
Chapter 17: Unlike the stochastic events that determine ageing, sex determines longevity. by: Leonard Hayflick

Index