Cell and Gene Therapies for Neurologic Diseases

ISBN-13: 9780323901208 / Angielski

Howard J. Federoff; Roger A. Barker

Spis treści

Section 1- Cellular Therapies1. Introduction to stem cell biologyo Yamanaka, Gurdon, Rao, Thomson, Gage, Studer, Parmar 2. History of cellular graftingo Lindvall/Bjorklund or Steve Dunnett3. Allogenic vs Autologous approacheso Federoff/Jun and Masayo TakahashiSection 2- Gene therapies4. Introduction to methods of gene transfero Samulski, Xiao, Mulligan, Glorioso, Breakefield5. History of gene therapy (and recombinant DNA)o Verma, During, Wilson6. Role the RAC (USA)o Patterson, Corrigan-Curay7. Viral vs Non-viral approacheso Mart Saarma (Finland)Section 3- General Considerations (and perhaps combine these sections for cell and gene therapies)8. Clinical/surgical considerationso Barker, Palfi, Tom Foltynie9. Ethical considerationso Charo, Macklin, Kaplan, Jonathan Sugarman10. Manufacturing considerationso Melissa Carpenter/Jacqueline Barry (Cell & Gene Therapy Catapult UK)11. Clinical trial designs and clinical endpointso Karl Kieburtz/ Tony Lang12. Immunology of such therapieso Hakan Widner; Emanuele Cozzi13. Role of neuroimaging/biomarkerso Paola Piccini/Jon Stoessel/David Eidelberg14. Scaling to populationo Andreas Bosio/Stefan Irions15. Health economics and outcomeso TBDSection 4- Disease specific interventions using cells and genes16. Parkinson's Diseaseo Barker17. Huntington's Disease o Rosser18. ALS o Svendsen19. Stroke o Kakaia20. AMD o Coffey21. Spinal cord o Armin Curt22. Retinitis Pigmentosa o Ali23. Demyelination o Goldman24. Epilepsy o Kriegstein Section 5- Gene Therapies.25. Clinical/surgical considerationso Larson, Bankiewicz, Kaplitt, Gross, Rothstein26. Ethical considerationso Kahn27. Manufacturing considerationso Robin Ali28. Clinical trial designs and endpointso Kieburtz, Olanow, Ravina29. Role of neuroimaging/biomarkerso Eidelberg, Stossel30. Scaling to populationso Lonser31. Health economics and outcomeso Roan-Gresenz, others