Cell Therapy for Perinatal Brain Injury

ISBN-13: 9789811014116 / Angielski / Twarda / 2018 / 150 str.

Haruo Shintaku; Akira Oka; Makoto Nabetani

Opis

This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

Recenzje

"This book reviews advances the evolving cell therapy for various neonatal ischemic diseases. It has 14 chapters, with tables, illustrations and many references. For pediatric neonatologists, hematologists and researchers in biology." (Pediatric Endocrinology Reviews (PER), Vol. 16 (1), September, 2018)

"The book is aimed mostly at researchers, especially those involved in stem cell therapy. However, neonatologists and pediatric neurologists will find the concepts intriguing and sometimes exciting. The authors seem to be well regarded in this field. ... This is a provocative monograph that certainly could inform discussions on this cutting-edge therapy. ... For those curious about this novel therapy, this is an interesting read." (Jay P. Goldsmith, Doody's Book Reviews, May, 2018)

Spis treści

1. Clinical trial of autologous cord blood cell therapy for neonatal hypoxic‐ischemic encephalopathy (HIE).- 2. New strategy of clinical studies for premature babies with ischemic brain damage .- 3. Pathophysiology and pathology of neonatal hypoxic-ischemic encephalopathy.- 4. Neural stem/progenitor cells for perinatal brain injury.- 5. Hematopoietic stem cells for perinatal brain injury.- 6. Umbilical cord-derived mesenchymal stromal cells for perinatal brain injury.- 7. Other tissues-derived mesenchymal stem cells for perinatal brain injury.- 8. CD34+ cell in cord blood and neonates.- 9. The History of Hypothermia therapy for perinatal ischemic brain injury.- 10. Clinical Procedure of Cell Therapy (Cord blood collection).- 11. Clinical Procedure of Cell Therapy (Separation and infusion).- 12. Cell therapy for adult infarction.- 13. Clinical trials on cell therapy for perinatal brain injury: Challenges and opportunities.- 14. A new prospective cell therapy for neonatal brain injury.

O autorze

Haruo Shintaku

Department of Pediatrics,

Osaka City University Graduate School of Medicine,

Osaka

Japan

Akira Oka

Department of Pediatrics,

University of Tokyo, 

Tokyo

Japan

Makoto Nabetani, 

Department of Pediatrics,

Yodogawa Christian Hospital, 

Osaka,

Japan