Cell Therapy for Brain Injury

ISBN-13: 9783319150628 / Angielski / Twarda / 2015 / 369 str.

David C. Hess

Opis

Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.

Spis treści

Introduction to Cell Therapy in Brain Injury.- Cell Based Therapeutics in Stroke: An Industry Perspective.- Autologous Mesenchymal Stem Cell Therapy in Patients with Stroke.- Treatment of Autologous Bone Marrow Mononuclear Cells for Acute and Subacute Stroke: Cell-Therapy for Acute/Subacute Stroke.- Clinical Development of MultiStem® for Treatment of Injuries and Diseases of the Central Nervous System.- Intra-Arterial Approaches to Stem Cell Therapy for Ischemic Stroke.- Neural Stem Cells in Stroke: Intracerebral Approaches.- The CTX Human Neural Stem Cell Line and the PISCES Stroke Trial.- Induced Pluripotent Stem Cells as a Cell-based Therapeutic in Stroke.- Induced Pluripotent Stem Cell Derived Neural Cell Types In Treatment of Stroke.- Preconditioning and Cell-based Therapeutics.- Tracking of Administered Progenitor Cells in Brain Injury and Stroke by Magnetic Resonance Imaging.- Biomaterials Application in Stem Cell Therapies for Stroke.- A Stem Cell Derived Cell-Free Therapy for Stroke: Moving Conditioned Medium into Clinical Trial.- Pathophysiology of Traumatic Brain Injury: Rationale and Role for Cellular Therapies.- Stem Cell Therapy for Neonatal Hypoxic-Ischemic Brain Injury.- Cell-Based Therapies in Neonatal Stroke.- Issues in Clinical Trial Design in Stem Cell Trials after Stroke.

O autorze

Dr. David C. Hess, MD is currently Chairman and Professor, Department of Neurology, Joint Appointment, Institute of Molecular Medicine and Genetics and Joint Appointment, College of Graduate Studies at Georgia Regents University. He completed his MD at University of Maryland Medical College of Georgia in Baltimore and an internship and residency in Internal Medicine at Allegheny General Hospital in Pittsburgh, before completing an additional residency in Neurology at Georgia Health Sciences University in Augusta. Dr. Hess has authored or co-authored more than 150 papers. This book reflects the intersection between Dr. Hess' clinical interest in stroke and his research interest in stem cells.

Blurb

This is a review of state-of-the-art cell therapy in the treatment of stroke, traumatic brain injuries and neonatal stroke and hypoxia-ischemia using a variety of cells ranging from bone marrow derived stem cells and mesenchymal stem cells to induced pluripotent stem cells derived neural progenitors.  This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke, approaches using conditioned medium, and the "big pharma" perspective of cell therapy. Each of eighteen chapters has been contributed by a well-known leader in each field, thus providing a wealth of international perspective and expertise. Cell Therapy for Brain Injury’s breadth makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.