Cell Therapy: Stem Cell Transplantation, Gene Therapy, and Cellular Immunotherapy

ISBN-13: 9780521473156 / Angielski / Twarda / 1996 / 647 str.

George Morstyn; William Sheridan; Karol Sikora

Opis

This volume examines the current state and future prospects of cell therapy. The coverage is broad, including the scientific principles of hematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy (including treatment of AIDS), and the principles and practice of cellular immunotherapy.

Recenzje

'… an excellent and timely text … strongly recommended …'. N. H. Russell, The Lancet

Spis treści

Part I. Aspects of Hematopoiesis: 1. Overview of hematopoiesis and review of cells needed for hematopoietic reconstitution; 2. Review of cells important for adoptive cellular immunotherapy; 3. Potential uses of defined cell populations; 4. Progenitor cell assays; 5. Flow cytometric techniques; 6. Principles of gene therapy; 7. Sources of progenitor cells; 8. Chemotherapy approaches to mobilization of progenitor cells; 9. Cytokine approaches to mobilization of progenitor cells; 10. Stem cell isolation; 11. Methods of cell selection using monoclonal antibodies; 12. Magnetic approaches to cell separation; 13. Growth factors and ex-vivo expansion of hematopoietic progenitor cells; 14. Bioreactors for expansion; 15. Purging of malignant cells; Part II. Current Clinical Approaches: 16. What can be achieved without cell therapy; 17. Clinical potential of hematopoietic growth-factor support for high-dose chemotherapy; 18. Review of high-dose chemotherapy requiring cellular support in solid tumors; 19. Review of high-dose chemotherapy requiring cellular support in hematological malignancies; 20. Review of the potential use of cell therapy in leukemia; Part III. Future Clinical Applications: 21. Clinical gene therapy; 22. Correction of inborn errors; 23. Cellular therapy approaches to the treatment of AIDS; Part IV. Experimental and Clinical Cellular Immunotherapy: 24. Adoptive immunotherapy with T cells; 25. Cellular adoptive immunotherapy with natural killer cells; 26. Autologous tumor cell vaccines; 27. Allogeneic cellular vaccines against tumors; 28. Neutrophil transfusions for treatment of infections; 29. Experimental and clinical cellular immunotherapy in bone-marrow transplantation; 30. Donor lymphocyte therapy in bone-marrow transplantation; 31. Graft-versus-leukemia effect in bone-marrow transplantation.