Cell Sources of Liver Development and Regeneration

ISBN-13: 9783659122071 / Angielski / Miękka / 2012 / 128 str.

Anisa Gumerova; Andrey Kiassov; Sayar Abdulkhakov

Opis

The central problem of modern hepatology is identification of a regional hepatic stem cell. Necessity of solving this problem is dictated by considerable prevalence of chronic liver diseases, insufficient efficiency of existing methods of their treatment, and as a consequence - by high frequency of liver fibrosis and cirrhosis development as an outcome of these diseases. Liver transplantation becomes the only possible method of treatment in these cases. However existing deficiency of donor organs, long waiting lists, high cost of transplantation and necessity of subsequent immunosuppression dictate necessity of search of new approaches in therapy of this group of diseases. Identification of the hepatic stem cell would allow development of essentially new methods in treatment of chronic liver diseases based on stimulation of autologous hepatic stem cells and application of cellular therapy including genetically modified stem cells. Therefore the aim of our research was to study differentiation of main hepatic cellular types (hepatocytes, cholangiocytes and sinusoidal cells), to determine possible cellular sources of their development and regeneration.

O autorze

Dr. A. Gumerova has obtained her PhD degree in Histology, Cytology and Embryology in 1999. She has worked at the department of Normal Human Anatomy of Kazan State Medical University (Russia). Research interests hepatic stem cells and cell-cell interactions during development and regeneration of the liver.