Cell Signaling in Vascular Inflammation

ISBN-13: 9781617376191 / Angielski / Miękka / 2010 / 222 str.

Jahar Bhattacharya

Opis

A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.

Spis treści

Heme Oxygenase-1 and Carbon Monoxide in Vascular Regulation Stefan W. Ryter and Augustine M. K. Choi Tumor Necrosis Factor-a/Receptor Signaling Through the Akt Kinase Osman Nidai Ozes, Hakan Akca, Jason A. Gustin, Lindsey D. Mayo, Roxana Pincheira, Chandrashekhar K. Korgaonkar, and David B. Donner Protein Modifications by Nitric Oxide and Reactive Nitrogen Species Harry Ischiropoulos Redox Signaling in Hypoxic Pulmonary Vasoconstriction E. Kenneth Weir, Zhigang Hong, Anthony Varghese, Daniel P. Nelson, and Andrea Olschewski cGMP-Dependent Protein Kinase in Regulation of the Perinatal Pulmonary Circulation Usha Raj, Yuansheng Gao, Srinivas Dhanakoti, and Fred Sander Glutamate Receptor Activation in the Pathogenesis of Acute Leg Injury Sami I. Said Carboxyl Methylation of Small GTPases and Endothelial Cell Function Sharon Rounds, Elizabeth O. Harrington, and Qing Lu Pressure-Induced Inflammatory Signaling in Lung Endothelial Cells Wolfgang M. Kuebler Regulation of Endothelial Barrier Function: Contributions of the Transcellular and Paracellular Pathways Dolly Mehta, Richard D. Minshall, and Asrar B. Malik Sphingolipid Signaling: Implications for Vascular Biology Margaret M. Harnett Regulations of Cytokine Signaling Bao Q. Vuong, Lisa McKeag, Julie A. Losman, Jianze Li, Alex Banks, Scott Fay, Peter Chen, and Paul Rothman Cell Signaling by Vasoactive Agents Barry L. Fanburg, Regina M. Day, Amy R. Simon, Sheu-Ling Lee, and Yuichiro J. Suzuki Reactive Oxygen Species and Cell Signaling in Lung Ischemia Aron B. Fisher Pulmonary Vascular Barrier Regulation by Thrombin and Edg Receptors Jeffrey R. Jacobson and Joe G. N. Garcia Second-Messenger Signaling in Lung Capillaries Kaushik Parthasarathi Plasma Membrane-to-Nucleus Calcium Signaling Giles E. Hardingham Signaling by Mitochondria Navdeep S. Chandel Pro-Inflammatory Signaling by Endothelial Focal Complexes in Lung Sunita Bhattacharya Hydrogen Peroxide As Intracellular Messenger: Production, Target, and Elimination Sue Goo Rhee, Tong-Shin Chang, Yun Soo Bae, Seung-Rock Lee, and Sang Won Kang Calcium-Inhibited Adenylyl Cyclase (AC6) Controls Endothelial Cell Barrier Function Troy Stevens Index

Blurb

Although inflammatory disease of the vascular bed of the lung is a major cause of morbidity and mortality in both adult and pediatric age groups, the importance of vascular biology to its understanding, and in developing novel therapeutics, has been overlooked. In Cell Signaling in Vascular Inflammation, leading basic and clinical researchers review the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement.
Authoritative and state-of-the-art, Cell Signaling in Vascular Inflammation offers physiologists, molecular and cell biologists, and pharmaceutical scientists a comprehensive survey of the signal transduction pathways in lung vascular cells that illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.