Cell Signaling & Molecular Targets in Cancer

ISBN-13: 9781461407294 / Angielski / Twarda / 2011 / 328 str.

Malay Chatterjee; Khosrow Kashfi

Opis

This book provides an overview of critical components of cell signaling machinery and its role in epithelial morphogenesis, proliferation, invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways.

Spis treści

Acknowledgement.- GRB2 Signaling as a Molecular Target for Cancer.- Human arylamine N-acetyltransferase 1 : from drug metabolism to drug target.- Targeting Argininosuccinate Synthetase in Cancer Therapy.- Parathyroid hormone-related peptide signaling in cancer.- Signaling Molecules as Selective Targets for Therapeutic Strategies in Multiple Myeloma.- Role of Bile Acids in Carcinogenesis of Gastrointestinal Tract.- AIB1: A Transcriptional Coactivator which Integrates Signaling Crosstalk in Cancer Cells.- Rational Design of DNA Anti-cancer Agent that Targets Signal Transducer and Activator of Transcription 3 (Stat3) for Cancer Therapy.- Estrogen Receptor Signaling in Lung Cancer.- Microparticle Dissemination of Biological Activities: Implications for Cancer Biology.- Protein Kinase D Signaling in Cancer.- Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer,Reactive Oxygen Species and Antioxidants.- PPARg, Thiazolidinediones, Lung Cancer.- Targeting Signal Transducer and Activator of Transcription (STAT) for Anti-Cancer Therapy.- Index  

 

 

 

   

  

 

 

 

   

  

 

 

   

Blurb

The abnormal behavior of all cancer cells regardless of cancer type is irregular cell signaling pathway activity. A mechanistic approach dealing with a fundamental and molecular view based signaling cascade are exciting and dynamic areas of cancer research. This book illuminates what we know, how we know and what remains to be discovered in this regard. The book explore and identify not only the key compounds of cell signaling pathway but also the interaction between them, the cross-talk. This book bring together up-to-date summaries of the signaling components that are likely to be used in diagnosis, prognosis and novel target for pharmaceutical intervention and therapeutic development and highlight the importance of molecular approach to clinical cancer research. A lot clinical trials and outcome are promising.

The translation of recent advance in the knowledge of intracellular signaling into the generation of innovative molecular targeted cancer therapy are essential features of this book. Goals are manifold such as, resensitise chemoresistant target, capitalize on different mechanism of action and gain an advantage in the identification of best combination of drugs to induce clinically relevant response. The expert review compile in this book is an invaluable resource for graduate researcher and established scientist working in cell biology, pharmacy, experimental and molecular therapeutics and molecular medicine.