Cell Culture Engineering and Technology: In appreciation to Professor Mohamed Al-Rubeai

ISBN-13: 9783030798734 / Angielski / Miękka / 2023 / 550 str.

Ralf Pörtner

Opis

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Spis treści

Contents

Preface

Part I: Cell Engineering, novel technologies and the use of omics

1 Biopharmaceuticals Produced from Cultivated Mammalian Cells

Rasoul Al-Majmaie, Darrin Kuystermans, Mohamed Al-Rubeai

2 Remote Control of Mammalian Therapeutic Designer Cells

Maysam Mansouri, Martin Fussenegger (corresponding author)

3 Next generation cell engineering using microRNAs

Florian Klingler, Nadja Raab, Nikolas Zeh, Kerstin Otte (corresponding author)

4 An Omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production

Mauro Torres, Veronica Ortuzar, Alan J. Dickson (corresponding author), Hirra Hussain

5 Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations.

Ciara Lynch, Lynda Jordan, David O’Connell 

6 Monoclonal antibody glycoengineering for biopharmaceutical quality assurance

Itzcóatl Gómez Aquino, Ioscani Jiménez del Val (corresponding author)

7 Next-generation cell engineering platform for improving recombinant protein production in mammalian cells

Sung Wook Shin, Minji Kyeong, Jae Seong Lee (corresponding author)

Part II: Development of cell-based technologies and therapeutics

8 Manufacturing human pluripotent stem cells and differentiated progenitors

Svetlan Vassilev, Steve Kah Weng Oh (corresponding author)

9 Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications

Ross A. Marklein, Morgan Mantay, Cheryl Gomillion, James N. Warnock (corresponding author)

10 Process Design for hMSC Products in Stirred Tank Bioreactors 

Jan Barekzai, Florian Petry, Peter Czermak, Denise Salzig

11 Bio-production of Adeno-associated virus for gene therapy

Nicholas Donohue, Niamh Keogh, Stefano Boi, Niall Barron (corresponding author)

Part III: Cell culture process engineering, advanced bioreactor concepts, modelling, monitoring and control

12 scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale

Lucas Lemire, Phuong Lan Pham, Olivier Henry

13 Intensified and Continuous mAb Production with Single-Use Systems

Jan Müller, Misha Teale, Sandra Steiner, Stefan Junne, Peter Neubauer, Dieter Eibl, Regine Eibl (corresponding author)

14 Mathematical modelling of cell culture processes

Veronique Chotteau (corresponding author), Erika Hagrot, Liang Zhang, Meeri Mäkinen

15 Model-assisted design concepts for mammalian cell culture processes

Johannes Möller (corresponding author), Ralf Pörtner

16 Bioprocess monitoring and control

Jordi Joan Cairó, Martí Lecina (corresponding author)

17 Industrial Monitoring of Cell Culture

Sebastian Schwamb, Markus Engel, Tobias Werner, Philipp Wiedemann (corresponding author)

O autorze

​Prof. Dr.-Ing. Ralf Pörtner is a senior research associate and group leader at Technical University Hamburg, Institute of Bioprocess and Biosystems Engineering and Honorary Professor at TH Mittelhessen University of Applied Sciences, Giessen. The main research interests of Prof. Pörtner are development and optimization of bioreactor techniques and process strategies, in particular for cell cultures and microbial reactions, including model-based control concepts, and tissue engineering. He has in total published 135 peer-reviewed papers (H-index of 34).