Cell-Based Therapies in Stroke

ISBN-13: 9783709111741 / Angielski / Twarda / 2013 / 204 str.

Jukka Jolkkonen; Piotr Walczak

Opis

Stroke remains one of the main causes of death and disability worldwide. While effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.

Recenzje

"This is one of the several very good monographs published by Springer concerning the molecular, cellular, and translational models on animal and clinical stroke. The role of stem cells (bone marrow, umbilical, neural precursors & mesenchymal) derived transplants are discussed in separate chapters. ... The advantage of this book is it is very current discussing the most up to date journal data and analysis. This will guide active investigators with information guiding their animal and clinical research studies." (Joseph J. Grenier, Amazon.com, June, 2016)

"This book reviews the methodology of cell-based therapy and discusses potential applications. ... a valuable reference for researchers as well as clinicians who are interested in the evolving field of cell-based therapy. ... This book provides a balanced approach to cell-based therapy. ... The topics discussed here provide insight into the science of cell-based therapy. The information ... is for the most part presented in a manner readily understood by those who are not experts in the field." (Benjamin H. Eidelman, Doody's Book Reviews, August, 2013)

Spis treści

Preclinical Optimization of Cell Therapies: Cell Therapy and Structural Plasticity Following Cerebral Ischemia.- Delivery Routes for Cell Therapy in Stroke.- Different Sources of Stem Cells for Transplantation Therapy in Stroke.- Efficacy of Transplant and Endogenous Precursor and Stem Cell Interventions on Stroke Recovery.- Translational Imaging Techniques to Study Cell Therapy: Cell Labeling Methods for Non-Invasive MR Imaging of Stem Cells.- Strategies for Enhanced, MRI-guided Targeting of Stem Cells to Stroke Lesions.- Image-guided Injection and Non-invasive Monitoring of Tissue Regeneration in the Stroke-damaged Brain.- Tracking of Autologous VSOP-Labelled Mesenchymal Stem Cells in the Sheep Brain Using 3T MRI.- Neural Stem Cell Mapping With High Resolution Rapid Scanning X-ray Fluorescence Imaging.- In Vivo Biodistribution Studies and Cell Tracking in Stroke Using SPECT Imaging.- Early Phase Clinical Studies: Clinical Trials.- Intravenous Cell Therapies for Stroke.- Intra-arterial Cell Therapy in Stroke Patients.- Intraventricular Route of Cell Transplantation for Stroke-Related Diseases.

Blurb

Stroke remains one of the main causes of death and disability worldwide. Effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.