Catecholamines and the Heart: Recent Advances in Experimental and Clinical Research

ISBN-13: 9783642683237 / Angielski / Miękka / 2011 / 383 str.

W. Delius; E. Gerlach; H. Grobecker

Opis

An International Symposium "Catecholamines and the Heart" was held in Munich in May 1981, which was organized in cooperation with the Council on Cardiac Metabolism of the International Society and Federation of Cardiology and with the Microcirculation Working Group of the European Society of Cardiology. It was the aim of the organizers to evaluate in this Symposium the recent advances made in the field of sympathetic control of heart function. Particular attention was given to neural sympathetic pathways, to mechanisms and consequences of adrenoceptor stimulation and blockade as well as to clinically relevant implications mainly regarding the significance of catecholamines and of adrenoceptors in various heart diseases. The broad scope was covered in 34 papers presented by physiologists, pharmacologists and cardiologists during a two day meeting which was attended by an international audience. This book includes all papers as well as the discussions following each presentation. To accomplish rapid publication the manuscripts are published as submitted by the authors. The discussions were edited making use of the written questions and answers of the discussants. The Symposium was generously sponsored by Astra Chemicals GmbH, Wedell Holstein, Germany, which thus made possible a very fruitful exchange of information, ideas and concepts between specialists in various disciplines. The organizers gratefully acknowledge this support once again and would like to thank Dr. T. Kreuzer, the representative of Astra Chemicals, for his personal engagement.

Spis treści

I. Sympathetic Nerves and Adrenergic Receptors.- Regulation of Sympathetic Outflow to the Heart.- Relationship Between Sympathetic Outflow to Muscles, Heart Rate and Plasma Noradrenaline in Man.- Classification and Function of Adrenoceptors.- Role of Presynaptic and Postsynaptic Adrenoceptors in Cardiac Function.- Sympathetic Control of Coronary Circulation.- Identification of Cardiac Alpha-Adrenergic Receptors by Direct Binding Studies: Clinical Implications.- Identification and Characterization of Beta-Adrenergic Receptors in Myocardium Under Normal and Pathologic Conditions.- Catecholamines and ?-Adrenergic Receptors in the Non-Ischemic Myocardium After Coronary Occlusion.- Heart Catecholamines in Genetic Hypertension.- II. Biochemical and Physiological Implications of Adrenergic Receptor Stimulation.- Principles of Signal Transformations Mediated by Subtypes of Adrenergic Receptors.- Occurrence and Functional Significance of Cardiac Muscle Protein Kinases.- Cyclic AMP-Dependent Activation of Protein Kinases in the Myocardium.- Antiadrenergic Action of Adenosine in the Heart: Possible Physiological Significance.- Effects of Ionic Composition on Cardiac Sarcolemmal Adenylate Cyclase.- Catecholamines and Cardiac Adenine Nucleotide Metabolism.- Beta-Adrenoceptor Stimulation and Membrane Calcium Permeability.- The Problem of Catecholamine Oxygen Wasting in the Heart.- Effects of Adrenergic Stimulation and Inhibition on Infarcting Myocardium.- Catecholamines in Myocardial Hypoxia and Ischemia.- III. Pathophysiological, Clinical and Therapeutic Aspects of Catecholamines and Adrenergic Receptors.- Myocardial Catecholamines and Biosynthetic Enzymes in Various Heart Diseases of Man.- Catecholamines in Patients with Coronary Heart Disease.- Catecholamines in Patients with Heart Failure.- Lymphocyte Beta-Adrenoreceptor Function in Congestive Heart Failure: Modulation by Dopamine-Beta-Hydroxylase.- Provoked Coronary Arterial Spasm.- Catecholamines and Early Post-Infarction Arrhythmias: The Effects of ?- and ?-Adrenoceptor Blockade.- Different Types of Beta-Blocking Agents: Therapeutic Implications.- Myocardial Infarction and Beta-Adrenoceptor Blockade.- The Role of Beta-Adrenoceptor Blockade in Congestive Cardiomyopathy.- Comparison of Withdrawal Phenomena After Propranolol, Metoprolol and Pindolol.- Sympathomimetic Drugs in the Treatment of Congestive Heart Failure.- Effect of Vasodilator Therapy on Sympathetic Activity in Patients with Impaired Left Ventricular Function.- Beta-Blockers and Calcium Antagonists: Synergistic Effects.- Beta-Blockers and Calcium Antagonists: Mode of Action in Angina pectoris.- Beta-Blockers and Calcium Antagonists in Hypertrophic Obstructive Cardiomyopathy.