Casebook in Clinical Pharmacokinetics and Drug Dosing

ISBN-13: 9780071628358 / Angielski / Miękka / 2015 / 304 str.

Henry Cohen

Opis

A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug's pharmacology, including:

• Indications
• Mec hanisms of action
• Toxicities
• Pharmacokinetics

There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.

Spis treści

1. Amiodarone & Dronedarone
2. Aminoglycosides
3. Antibiotics Continuous Infusions and Intermittent Infusions
4. Antiepileptic Drugs: Second Generation/Newer Agents
5. Carbamazepine
6. Cyclosporine
7. Digoxin
8. Ethosuximide
9. Lidocaine
10. Lithium
11. Depot Antipsychotics
12. Methotrexate
13. Phenobarbital & Primidone
14. Phenytoin & Fosphenytoin
15. Polymyxin & Colistin
16. Procainamide
17. Quinidine
18. Sirolimus and Tacrolimus
19. Theophylline
20. Valproic Acid
21. Vancomycin
22. Warfarin
23. Heparin and LMWH
24. DTIs oral and IV
25. Toxicokinetics
26. Dialysis
27. P-Glycoprotein Transporter Interactions
28. CYP-450 Interactions
29. Glucuronidation Interactions

O autorze

Henry Cohen, Pharm.D, MS (Brooklyn, NY) is Associate Professor of Pharmacy Practice at the Arnold & Marie Schwartz College of Pharmacy and Health Sciences of Long Island University in Brooklyn, New York.