Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders

ISBN-13: 9789814745581 / Angielski / Twarda / 2017 / 586 str.

Andreia Ascenso; Helena Ribeiro; Sandra Simoes

Opis

This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management. Photodynamic therapy and melatonin can be used in the photocarcinogenesis context, too. Therefore, the inclusion of this strong antioxidant in sunscreen products could be a promising approach. The book discusses topical formulations, including emulsions (conventional formulations and emulsions stabilized by solid particles), nail films, and nanocarriers used for the delivery of actives in various skin and nail diseases such as acne, psoriasis, atopic dermatitis, fungal diseases, leishmaniasis, and skin cancer. Finally, several nanocarriers are introduced, such as lipid vesicles (ranging from the first-generation conventional liposomes to the more recent deformable vesicles), liquid crystalline nanodispersions, gelatin, and solid lipid nanoparticles. Their composition, formulation, characterization, and topical applications are also discussed. Although this is a broad topic, the most important (nano)pharmaceutical formulations are presented in the book.

Spis treści

New Approaches for Skin Aging and Photocarcinogenesis. New trends in anti-aging skin care. Melatonin, a "guardian" of the genome and cellular integrity for prevention of photocarcinogenesis. Safety and efficacy of sunscreen formulations containing carrier or non-carrier-based UV-filters. Topical photodynamic therapy for skin diseases: The current status of preclinical and clinical research, nanocarriers and physical methods for photosensitizer delivery. Delivery Systems and Nanocarriers for Topical Route: Examples and Illustration of Some Therapeutic and Cosmetic Applications. Novel starch-derived topical delivery systems. Solid lipid nanoparticles and nanostructured lipid carriers as topical delivery systems for antioxidants. Manufacturing and applications of gelatin nanoparticles: A practical approach. Lipid vesicles for skin delivery: Evolution from first generation. Archaeosomes for skin injuries. Ethosomes: A novel carrier for dermal or transdermal drug delivery. Lipid-based nanocarriers for the treatment of infected skin lesions. Liquid crystals as drug delivery systems for skin applications. Cyclodextrins and skin disorders: Therapeutic and cosmetic applications. Topical formulations for onychomycosis: A review.