Cardiovascular Research: New Technologies, Methods, and Applications

ISBN-13: 9780387233284 / Angielski / Twarda / 2005 / 239 str.

Gerard Pasterkamp; Dominique Pv de Kleijn

Opis

In the last decade, technical improvements have changed the inventory of many research laboratories. New techniques and discoveries continuously give rise to observations that result in the de?nition of new research objectives. In the past, - search departments were clearly demarcated. Nowadays, technology that is shared by all lines of research stimulates convergence of research interests. This also - plies to cardiovascular research. Vascular occlusive disease is now core business for researchers employed by cardiology, vascular surgery, vascular medicine, - diology, cell biology, chemistry, physiology, and many other areas. Knowledge on actual research development is shared by researchers with different skills. It is sometimes dif?cult to acquire expertise when a researcher feels his experimental work could be improved by introducing a new research technique. In this book, the investigator will ?nd an overview of recent developments that are relevant for research in general but cardiovascular research in particular. Genomics, p- teomics, microarray, RNAi, stem cells, and progenitor cells are just some phrases that have become increasingly prevalent in literature in the last few years and that are recognized by many, but are fully understood by few. In this book, experts share the most appreciated new developments and techniques in cardiovascular research. We hope that this book will help the reader who is working in the ?eld of cardiovascular research to understand and critically appreciate current research, and that it will help improve the quality of experimental work. Dr G.

Spis treści

Methods.- Expression Profiling in Cardiovascular Disease Using Microarrays.- Proteomics: State of the Art and Its Relevance for Gene Therapy.- Cardiovascular Proteomics.- Quantitative Real-Time PCR.- New Technologies in Cardiovascular Research: Gene Therapy.- The Role of Bioinformatics in Genomic Medicine.- RNA Interference Mechanisms and Therapeutic Applications.- Applications.- Stem Cells and Cardiomyocytes.- Can Somatic Stem Cells Regenerate Myocardial Tissue?.- Gene Therapy for Angiogenesis.- Tissue Engineering.- Visualization of the Vulnerable Plaque.

Blurb

Cardiovascular Research: New Technologies, Methods & Applications serves as an essential reference material offering a complete overview of innovative new technologies, methods, and applications in current cardiovascular research. Cardiovascular Research: New Technologies, Methods & Applications presents a methods and applications approach to cardiovascular research written by prominent international researchers presenting commissioned summaries of cutting edge research.

Key Topics:

Offers a Methods and Applications approach including, Cardiovascular Methods in:

-Microarrays

-Proteomics

-Real Time PCR

-RNA Interference

-Plus More!

Cardiovascular Applications in:

-Stems Cells and Cardiomyocytes

-Stem Cells and Angiogenesis

-Gene Therapy

-Manufacturing the Artificial Blood Vessel

-Closed Chest Robotic Surgery

-RNA Interference

-Plus More!

Cardiovascular Research: New Technologies, Methods & Applications is essential for all cardiovascular research academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in the continuously emerging field of cardiovascular science.

About the Editors:

Gerard Pasterkamp, PhD, MD is Associate Professor and Head of Experimental Cardiology Laboratory at the Heart Lung Centre Utrecht at the University Medical Center Utrecht (UMCU). Dr. Pasterkamp received his MD at Free University Amsterdam, his PhD at the medical faculty on intravascular ultrasound, and his MSc Clinical Epidemiology at the NIHES Rotterdam. Dr. Pasterkamp's many original papers and invited reviews on the topic of vascular remodeling reveal his skilled interest in arterial remodeling in atherosclerotic disease.

Dominique de Kleijn, PhD is a molecular biologist at Interuniversity Cardiology Institute of the Netherlands (ICIN) and is positioned at the Laboratory of Experimental Cardiology at the UMCU. Dr. Klein earned his PhD molecular biology at the Nijmegen University at the Department of Molecular Animal Physiology, and is recognized as an expert in matrix biology and innate immunity in cardiovascular disease.