Cardiovascular Genomics

ISBN-13: 9781617375422 / Angielski / Miękka / 2010 / 362 str.

Mohan K. Raizada; Julian F. R. Paton; Michael J. Katovich

Opis

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

Recenzje

From the reviews:

"'Cardiovascular Genomics' provides an up to date account of genes that are important in cardiovascular health and disease. ... For those who require a concise, well-researched and written collection on some of the ways that cardiovascular diseases are being tackled from the laboratory to the patient bedside, this book will provide an excellent choice in this fast paced area of research." (S. Loughna, Human Genetics, Vol. 121, 2007)

Spis treści

Part I. Genes and Polymorphisms in Cardiovascular Disease Angiotensin II Receptor Polymorphisms and Hypertension Bruno Baudin Angiotensinogen Gene Polymorphisms and Hypertension Ashok Kumar Substitution Mapping: Using Congenic Strains to Detect Genes Controlling Blood Pressure Bina Joe and Michael R. Garrett Local Production of Angiotensinogen: Insights From Genetic Manipulation of Mice Kamal Rahmouni and Curt D. Sigmund Cardiovascular Pharmacogenomics Julie A. Johnson and Larisa H. Cavallari Genetic Polymorphisms and Response to HMG-CoA Reductase Inhibitors Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, and Anthonius de Boer Monogenic Causes of Heart Failure: Familial Dilated Cardiomyopathy Hideko Kasahara Part II. Gene Transfer for Combating Cardiovascular Disease Gene Therapy vs Pharmacotherapy Ryuichi Morishita Molecular Therapeutic Approaches for Myocardial Protection Alok S. Pachori, Luis G. Melo, and Victor J. Dzau Gene Transfer and the Cardiovascular System William H. Miller, Stuart A. Nicklin, Andrew H. Baker, and Anna F. Dominiczak Kallikrein Gene Transfer in Hypertension, Cardiovascular and Renal Disease, and Stroke Julie Chao and Lee Chao Current and Future Novel Targets of Gene Therapy for Hypertension Michael J. Katovich, Justin L. Grobe, and Mohan K. Raizada Application of Viral Gene Transfer in Studies of Neurogenic Hypertension Sergey Kasparov, A. G. Teschemacher, and Julian F. R. Paton Vigilant Vectors: Intelligent Gene Vectors for Cardioprotection in Myocardial Ischemia M. Ian Phillips and Yi Tang Gene Therapy for Cerebral Arterial Diseases Yoshimasa Watanabe and Donald D. Heistad Part III. Regenerative Tissues for the Diseased Cardiovascular System Therapeutic Angiogenesis and Vasculogenesis for Tissue Regeneration Paolo Madeddu Cell Transplantation: The New Frontier Shafie Fazel, Paul W. M. Fedak, Richard D. Weisel, Denis Angoulvant, Terrence M. Yau, and Ren-Ke Li Embryonic Stem Cells and the Cardiovascular System Neta Lavon and Nissim Benvenisty Index

Blurb

After more than 50 years of limited success in controlling blood pressure with traditional antihypertensive drugs, the time is ripe to explore alternate strategies for managing cardiovascular diseases. In Cardiovascular Genomics, recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. They involve genetic linkage analysis and substitution mapping using congenic strains, microarray techniques, and strategies for discovery in animal models of hypertension. The new transgenic mouse models that either over- or underexpress angiotensinogen are used to illuminate the function of the tissue renin-angiotensin systems, enhancing the understanding of the role of polymorphisms, a crucial factor for effective design of new drugs. The chapters on gene transfer and gene therapy cover a wide variety of topics ranging from novel clinical applications for treating stroke, coronary, and peripheral vascular diseases, to producing new cardiovascular cells and tissues, to using viral vectors as tools. A value-added compact disk containing a companion ebook version of Cardiovascular Genomics is included for downloading and use in the reader's PC or PDA.
Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both cutting-edge scientific approaches through the new science of cardiovascular genomics, and the efficacious results it is now possible to obtain.