Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists

ISBN-13: 9783642705014 / Angielski / Miękka / 2011 / 511 str.

A. Fleckenstein; C. Van Breemen; R. Gross

Opis

Held at Boppard, Germany, October 3-6, 1984

Spis treści

Welcome.- Calcium Antagonists and Calcium Agonists: Fundamental Criteria and Classification.- With 18 Figures and 5 Tables.- Session I: Ca-Channels.- Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists.- With 12 Figures.- Discussion.- Ca Entry into Vascular Smooth Muscle.- With 11 Figures.- Discussion.- Calcium Currents in Mammalian Central Neurones.- With 3 Figures and 1 Table.- Discussion.- Session II: Molecular Interactions.- Chemistry of Dihydropyridines.- Structure-Function Relationships of 1,4-Dihydropyridines: Ligand and Receptor Perspectives.- With 6 Figures and 2 Tables.- Discussion.- Calcium Channels: Introduction into Their Molecular Pharmacology.- With 15 Figures and 4 Tables.- The Dihydropyridine Receptors.- A Proposed Pharmacological Role for Dihydropyridine Binding Sites in Heart and Coronary Smooth Muscle.- With 21 Figures and 3 Tables.- Discussion.- Session III: Myocardial Effects.- The Effects of 1,4-Dihydropyridine Type Ca2+-Channel Antagonists and Agonists on Intracellular [Ca2+] Transients Accompanying Twitch Contraction of Heart Muscle.- With 5 Figures.- Discussion.- Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridines.- With 10 Figures.- Discussion.- Effects of the Calcium Agonistic Dihydropyridine Bay K 8644 on the Heart.- With 16 Figures.- Discussion.- Myocardial Effects of Dihydropyridines in Patients.- With 5 Figures and 2 Tables.- Discussion.- Session IV: Effects on Smooth Muscle.- Effect of Dihydropyridines on Visceral Smooth Muscle.- Discussion.- Effects of Ca2+ Antagonists on Isolated Rabbit Mesenteric Resistance Vessels as Compared to Rabbit Aorta.- With 6 Figures and 3 Tables.- Discussion.- Effect of Dihydropyridine Calcium Channel Modulators on Isolated Peripheral and Cerebral Vessels.- With 11 Figures and 1 Table.- Discussion.- Effects of Ca+ +-Agonistic and Ca+ +-Antagonistic 1,4-Dihydropyridine Compounds on Tonic and Phasic Activation of Extramural Coronary Vasculature.- With 14 Figures and 2 Tables.- Discussion.- Effects of Dihydropyridines on Human and Animal Isolated Vessels.- With 10 Figures and 1 Table.- Discussion.- Endothelium-Dependent Vascular Relaxation.- With 2 Figures.- Discussion.- Session V: Circulation.- Coronary and Systemic Hemodynamic Effects of Dihydropyridines.- With 10 Figures and 3 Tables.- Discussion.- Effect of a Dihydropyridine-Type Calcium Antagonist on Cerebral Blood Flow and Metabolism.- With 2 Figures and 4 Tables.- Discussion.- Calcium, Dihydropyridines and Resistance Vessel Tone.- With 1 Figure and 1 Table.- Discussion.- Differences Between Dihydropyridine and Non-Dihydropyridine Calcium Antagonists in Inotropic, Chronotropic, Dromotropic and Vascular Effects: Differences in Underlying Mechanism.- With 6 Figures and 2 Tables.- Discussion.- Effects of Calcium Antagonists on Fixed and Dynamic Obstructions in Patients with Severe Coronary Artery Disease.- With 14 Figures and 5 Tables.- Discussion.- Session VI: Hypertension.- Effects of Calcium Antagonistic and Agonistic Dihydropyridines on Experimental Hypertension and Vascular Damage.- With 7 Figures.- Discussion.- On the Antihypertensive Properties of Nitrendipine, with Observations of Its Effects on Electrolyte Excretion.- With 3 Figures and 5 Tables.- Discussion.- The Use of Calcium Antagonists in the Treatment of Arterial Hypertension.- With 3 Figures.- Discussion.- Calcium Antagonists for Identification of Mechanisms and Treatment in Patients with Essential Hypertension.- With 2 Figures.- Discussion.- Session VII: Tissue Protection.- Dihydropyridines and the Protection of the Ischaemic and Anoxic Myocardium.- With 7 Figures and 4 Tables.- Discussion.- Protection Against Complete Cerebral Ischemia by Nimodipine.- Discussion.- Interdependence of Antihypertensive, Anticalcinotic, and Antiarteriosclerotic Effects of Calcium Antagonists — Model Experiments on Spontaneously Hypertensive Rats (SHR).- With 9 Figures and 2 Tables.- Discussion.