Cardiomyopathies: Realisations and Expectations

ISBN-13: 9783642776007 / Angielski / Miękka / 2011 / 315 str.

John F. Goodwin; Eckhardt G. J. Olsen

Opis

This book reviews the basic knowledge about the cardiomyopathies and re-enforces the well-known definitions and classification of cardiomyopathies and specific heart muscle diseases, respectively. It emphasizes the importance of maintaining the classification into hypertrophic, dilated and restrictive cardiomyopathies, even though there are exceptions. The term "realisations" in the title is used in the sense of "achievements" and alludes to the progress in the understanding of heart muscle diseases over the last three decades and also to the areas of knowledge still not fully explored, for example, the as yet un classified putative cardiomyopathies such as arrhythmogenic right ventricular dysplasia, long QT syndrome and syndrome X. The accurate and sensitive identification of major risk factors for sudden death in hypertrophic cardiomyopathy needs further study, as do the implications of a familial basis in some patients with dilated cardio myopathy. The "expectations" mentioned in the title centre around the molecular biological aspects of viral myocarditis and dilated cardio myopathy and their relationship to each other; around the auto immune basis for dilated cardiomyopathy and its implications for drug therapy and cardiac transplantation; and around molecular genetic techniques for identifying the genes involved in hypertrophic cardiomyopathy that will be developed further. These will have implications for pre-natal recognition and for diagnosis in early life in apparently fit and active persons, and offer better prospects of prevention and cure."

Spis treści

I. Introduction.- 1 Definition, Classification and Terminology.- II. Dilated Cardiomyopathy.- 2 Clinical Aspects.- 3 Pathology.- 4 Clinical Investigation: New Approaches.- 5 Prognosis and Management.- III. Hypertrophie Cardiomyopathy.- 6 Clinical Aspects.- 7 Pathology.- 8 Clinical Investigation: Current Approaches.- 9 Haemodynamic Disorders: Management and Prognosis.- IV. Restrictive Cardiomyopathy.- 10 Clinical Aspects.- 11 Pathology.- 12 Doppler Echocardiographic Investigations.- V. Amyloid Heart Disease and Others.- 13 Amyloid Heart Disease and Cardiomyopathies Difficult to Classify.- VI. Experimental, Clinical, Immunological and Molecular Biological Research.- 14 The Significance of Autoantibodies and the Role of the ADP/ATP Carrier in the Pathogenesis of Viral Heart Disease, Myocarditis and Dilated Cardiomyopathy.- 15 Experimental Studies of Humoral and Cellular Immunological Parameters of Viral Heart Disease.- 16 Enteroviral Heart Muscle Disease: Current Molecular Studies and Future Research..- 17 The Molecular Genetics of Familial Hypertrophic Cardiomyopathy.