Cardiac Electrophysiology Methods and Models

ISBN-13: 9781441966575 / Angielski / Miękka / 2010 / 492 str.

Daniel C. Sigg; Paul A. Iaizzo; Yong-Fu Xiao

Opis

"Cardiac Electrophysiology Methods and Models" reviews key research methods and protocols in cardiac electrophysiology with a focus on advantages, pitfalls, practical implementation and collaborative cross-functional research.

Recenzje

From the reviews:

"Written by clinicians who have had a major impact on arrhythmia research, this book explains important methods and protocols that have been used in electrophysiology research. ... It is intended for health science students, physicians in training, and practicing cardiologists, especially electrophysiologists and those interested in pursuing a career in electrophysiology. ... This book nicely illustrates how skillful and thoughtful research at the cellular level can lead to new innovation that can be integrated into the care of patients." (Joseph Sam Owen, Doody's Review Service, April, 2011)

Spis treści

Clinical Cardiac Electrophysiology: An Overview of Its Evolution.- Clinical Cardiac Electrophysiology: An Overview of Its Evolution.- Overview.- Basic Cardiac Electrophysiology: Excitable Membranes.- Cardiac Action Potentials, Ion Channels, and Gap Junctions.- Anatomy and Physiology of the Cardiac Conduction System.- The Electrocardiogram and Clinical Cardiac Electrophysiology.- Methods and Models.- Principles of Electrophysiological In Vitro Measurements.- Cardiac Cellular Electrophysiological Modeling.- Computer Modeling of Electrical Activation: From Cellular Dynamics to the Whole Heart.- Detection and Measurement of Cardiac Ion Channels.- Cell Culture Models and Methods.- Isolated Tissue Models.- Isolated Heart Models.- Small Animal Models for Arrhythmia Studies.- Use of Large Animal Models for Cardiac Electrophysiology Studies.- Optical Mapping and Calcium Imaging.- Electrophysiology of Single Cardiomyocytes: Patch Clamp and Other Recording Methods.- Invasive Electroanatomical Mapping and Navigation.- Cardiac Electrophysiological Imaging: Solving the Inverse Problem of Electrocardiography.- Traditional Electrophysiological Mapping.- Multi-channel System for Analysis of Cardiac Rhythmicity and Conductivity In Vitro.- Cardiac CT/MRI Imaging for Electrophysiology.- Putting It All Together.- to Translational Research.- Clinical Perspective: Electrophysiology in the Young and Patients with Congenital Heart Disease.

O autorze

Daniel C. Sigg, MD, PhD is Adjunct Assistant Professor of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA Paul A. Iaizzo, PhD PhD is Professor of Surgery, Integrative Biology and Physiology and The Carlson School of Management, he is also Director of Education of the Lillehei Heart Institute and Associate Director for the Institute for Engineering in Medicine, he also holds the Medtronic Professorship for Visible Heart Research , University of Minnesota, Minneapolis, Minnesota, USA Yong-Fu Xiao, MD, PhD is Principal Scientist at Medtronic, Inc., New Therapies & Diagnostics Management, Cardiac Rhythm Disease Management, Mounds View, MN, USA Bin He, PhD is Distinguished McKnight University Professor and Professor of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA

Blurb

Biomedical, pharmaceutical and medical personnel are interested in studying aspects of arrhythmias at a basic, translational and applied level. The overall understanding of the molecular basis of disease has dramatically increased, as well as the number of available and emerging molecular, pharmacological and device treatment based therapies. Cardiac Electrophysiology Methods and Models will review key research methods and protocols in cardiac electrophysiology with a focus on advantages, pitfalls, practical implementation and collaborative cross-functional research.