Cardiac Cell Culture Technologies: Microfluidic and On-Chip Systems

ISBN-13: 9783319889795 / Angielski / Miękka / 2018 / 234 str.

Zbigniew Brzozka; Elzbieta Jastrzebska

Spis treści

Introduction.- Microfluidic Systems.- Lab-on-a-chip Systems for Cellomics – Materials and Technology.- Organ-on-a-chip Systems.- Biological Bases of Cardiac Function and the Pro-Regenerative Potential of Stem Cells in the Treatment of Myocardial Disorder.- Pluripotent and Mesenchymal Stem Cells - Challenging Sources for Derivation of Myoblast.- Microfluidic Systems for Cardiac Cell Culture – Characterization.- Heart-on-a-chip Systems.- Cardiac Cell Culture Microtechnologies Based on Stem Cells.

O autorze

Zbigniew Brzozka is Professor in the Chair of Medical Biotechnology and Head of the Lab-on-a-Chip group at Warsaw University of Technology.

Elzbieta Jastrzebska is Assistant Professor in the Chair of Medical Biotechnology at Warsaw University of Technology.

Blurb

• Microfluidic systems for cardiac cell culture are discussed based on tested cells and the methods of cardiac cell stimulation;
  
• The use of stem cell stimulation into cardiac cells in microfluidic systems is discussed in the context of electrical, biochemical, physical, and mechanical stimulations;
  
• Provides an overview of the measurements and data that can be extracted from on-chip systems for use in diagnostics, drug discovery and screening, and clinical therapy. 
  

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.