Carbohydrates in Drug Discovery and Development: Synthesis and Application

ISBN-13: 9780128166758 / Angielski / Miękka / 2020 / 700 str.

Vinod K. Tiwari

Spis treści

1. Recent trends and challenges on carbohydrate-based molecular scaffolding: general consideration toward impact of carbohydrates in drug discovery and development
2. Heparin mimetics as tools for modulation of biology and therapy
3. Bioactive C-glycosides inspired from natural products toward therapeutics
4. 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) derivatives in antibacterial drug discovery
5. Sialic acid-containing molecules in drug discovery and development
6. Glycan microarray: Toward drug discovery and development
7. Recent developments in the synthesis of biologically relevant Iinositol derivatives
8. Iminosugars in medicinal chemistry
9. Carbohydrate-protein interactions: Enhancing multivalency effects through statistical rebinding
10. Carbo-click in drug discovery and development: Opportunity and challenges
11. Glycohybrids molecule in medicinal chemistry: Present status and future prospective
12. Biologically active carbohydrate-containing macrocycles
13. Carbohydrate-based antibiotics: Opportunities and challenges
14. Carbohydrate-based anti-bacterial and anti-cancer vaccines
15. Opportunity of plant oligosaccharides and polysaccharides in drug development
16. N-acetylgalactosamine (GalNAc)-conjugates: Delivering oligonucleotide drugs to the liver

O autorze

Vinod K. Tiwari is an Associate Professor of Organic Chemistry at Banaras Hindu University, India. Dr. Tiwari has taught almost all branches of organic chemistry for the last 16 years. His current research focuses on synthetic carbohydrate chemistry. Dr. Tiwari has supervised twelve PhD theses and his research has been documented in 140 peer-reviewed publications. Additionally, Dr. Tiwari holds several patents & has written book chapters which have received awards from various academic societies. He is a highly-travelled scientist and has delivered over 155 invited lectures in India and abroad. Currently, Dr. Tiwari holds the position of Secretary for the Association of Carbohydrate Chemist and Technologists in India.