Candida Albicans: Cellular and Molecular Biology

ISBN-13: 9783319843940 / Angielski / Miękka / 2018 / 554 str.

Rajendra Prasad

Spis treści

1. Fungal infections

John E Edwards1 and Priya Uppuluri2

UCLA David Geffen School of Medicine, USA. 1E-mail: jedwards@labiomed.org , 2E-mail: puppuluri@labiomed.org

2. Fungal infections- The South-Asian perspective

Arunaloke Chakrabarti

Division of Mycology, Postgraduate Institute of Medical Education & Research, Chandigarh, India. E-mail: arunaloke@gmail.com

3. Regulatory pathways during C. albicans infections

Aaron P. Mitchell

Mellon Institute, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, USA. E-mail: apm1@andrew.cmu.edu

4. Virulence mechanisms and regulation

Christophe D’Enfert

Fungal Biology and Pathogenicity Unit - INRA USC2019, Department of Mycology, Institut Pasteur, Paris, France. E-mail: christophe.denfert@pasteur.fr

5. Signalling mechanisms in pathogenesis and virulence of C. albicans 

6. Biofilm development by C. albicans

David Andes

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison WI, USA. E-mail: dra@medicine.wisc.edu

7. Biofilm development and resistance mechanisms by C. albicans

Patrick Van Dijck1 and Mary-Ann Jabra Rizk2

1 VIB Department of Molecular Microbiology, KU Leuven, Kasteelpark, Arenberg, Leuven, Belgium. 2 University of Maryland School of Dentistry, Maryland, USA. 1E-mail: Patrick.VanDijck@mmbio.vib-kuleuven.be, 2E-mail: MRizk@umaryland.edu

8. Biofilm of C. albicans : development and regulation

Ashraf S. Ibrahim1 and Priya Uppuluri2

9. Host immune responses during infections

Gordon Brown

The Institute of Medical Sciences, University of Aberdeen, Scotland. E-mail: gordon.brown@abdn.ac.uk

10. Mechanism of drug resistance 

Dominique Sanglard

Institute of Microbiology, University Hospital Lausanne and University Hospital Center, Lausanne, Switzerland. E-mail: Dominique.Sanglard@chuv.ch

11. Structure- function analyses of Multi-drug transporters

Richard D. Cannon 

Department of Oral Sciences, University of Otago, Dunedin, New Zealand. E-mail: richard.cannon@otago.ac.nz

12. All about MFS multi-drug transporter of Candida albicans

Rajendra Prasad1, Peer Abdul Haseeb Shah2 and Archana Redhu2

1Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity University, Haryana, India. 2Membrane biology Labo

ratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. 1E-mail: rp47jnu@gmail.com, rprasad@ggn.amity.edu

13. Inhibitors/Modulators of MDR transporters 

Attilio Di Pietro

Institute for the Biology and Chemistry of Protein,  Lyon, France. E-mail : a.dipietro@ibcp.fr

14. Inhibitors/Modulators of MDR proteins/transporters

Brian Monk

Department of Oral Sciences, University of Otago, Dunedin, New Zealand. E-mail: brian.monk@otago.ac.nz

15.  Anti-fungals

David Perlin

Public Health Research Institute Center, New Jersey Medical School - Rutgers, The State University of New Jersey, New Jersey, USA. E-mail: perlinds@umdnj.edu

16. Anti-microbial peptides

Joachim Ernst and Marc Swidergall

Institut für Mikrobiologie, Molekulare Mykologie, Heinrich-Heine-Universität, D-40225 Düsseldorf, Germany. E-mail: Joachim.Ernst@uni-duesseldorf.de

17.  Anti-candidial agents

Slawomir Milewski

Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Poland. E-mail: slamilew@pg.gda.pl

18. MDR1 and its regulation

Joachim Morschhäuser

Institut für Molekulare Infektionsbiologie, Universität Würzburg, Würzburg, Germany.

E-mail: joachim.morschhaeuser@uni-wuerzburg.de

19.  Genomics and Anti-fungal resistance

Kaustuv Sanyal

Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India. E-mail: sanyal@jncasr.ac.in

20. Genomics and Anti-fungal resistance 

Judith Berman

Dept. of Molecular Microbiology & Biotechnology, George Wise Faculty of Life Sciences, Tel Aviv University, Israel. E-mail: Jberman@post.tau.ac.il

21.  Lipids and Multi-drug resistance in Candida albicans

Rajendra Prasad1and Ashutosh Singh2

1Amity Institute of Integrative Sciences and Health and Amity Institute of Biotechnology, Amity University, Haryana, India. 2Department of Molecular Genetics and Microbiol

ogy, Stony Brook University, New York, USA. 1E-mail: rp47jnu@gmail.com, rprasad@ggn.amity.edu, 2E-mail: ashutosh.singh29@gmail.com

22.  Cell wall of Candida albicans and its role in virulence

Neil A. R. Gow

The Institute of Medical Sciences, University of Aberdeen, Scotland. 

E-mail: n.gow@abdn.ac.uk

23. Hyphal morphogenesis of C. albicans

Michael Lorenz

Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, USA. E-mail: Michael.Lorenz@uth.tmc.edu

24. Innate immune defences against fungal infections

Michael Yeaman

UCLA David Geffen School of Medicine, USA, E-mail: MRYeaman@ucla.edu

O autorze

Prof. Rajendra Prasad has recently joined Amity University, Gurgaon as Director of the Amity Institute of Biotechnology and Amity Integrative Sciences and Health. He is a former Professor & Dean of the School of Life Sciences at Jawaharlal Nehru University (JNU), New Delhi, where he served for 40 years in various capacities which included Chairman of Molecular Medicine and Rector (Pro-Vice-Chancellor). Holding a Ph.D. from the Central Drug Research Institute, Lucknow, Prof. Prasad has also served as a visiting professor at several universities and institutes, including the Ecole Normale Superieure – CNRS Paris, France; Catholic University, Louvain-la – Neuve, Belgium; Technical University, Valencia, Spain; Bristol Mayer Squib, Princeton, USA; University of Darmstadt, Germany; and New York Medical College, USA. 

Prof. Prasad is a recipient of the Royal Society Commonwealth Bursary, Alexander von Humboldt-Stiftung Fellowship, Welcome Foundation Grant, and the Mercator Professorship at the University of Bonn. He is an elected fellow of all Indian Science Academies, a European Commission Focal Point Coordinator, and a Research Ambassador, Germany. He is also currently Vice President of the Indian National Science Academy, New Delhi.

Prof. Prasad has published over 225 research papers and has handled 50 national and international grants. He is a leading molecular mycologist and has conducted trendsetting research in the area of antifungal clinical drug resistance.

Blurb

This book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, host–pathogen interactions, virulence, host immune system modulation, etc., in the last two decades.

 This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.