Cancer and Chemoprevention: An Overview

ISBN-13: 9789811025785 / Angielski / Twarda / 2017 / 173 str.

Summya Rashid

Opis

This book focuses on the most relevant, comprehensive and most recent advances on cancer and chemo prevention. It discusses broadly on Cancer in general, its hallmarks, classification, molecular mechanisms of the outbreak of cancer, factors and major mediators and pathways involved in the progression of cancer. It also discusses about the deregulation in proto oncogenes, tumor suppressor genes and DNA repair genes which marks important events towards progression of cancer. The book also talks about the stages of carcinogenesis, role of oxidative stress, inflammatory mediators and apoptosis including mechanisms of action. The proposed book discusses about chemoprevention in general with its importance in the present scenario; when the modern medicine has left us with no option to treat this deadly disease because of being non targeted, costly, unaffordable and associated toxicities. The book also discusses about the mitigation of multi drug resistance, angiogenesis by chemo prevention. Giving more emphasis to chemoprevention, the book also discusses about different chemoprevention strategies currently used in the management of cancer with a few examples of novel chemo preventive agents targeting cancer which have reached clinics and some being at pre-clinical stage. Lastly chemoprevention, its problems, future perspectives and the road ahead has been given. In short it summarizes the material for the reader, be it an undergraduate student, graduate, researcher or an academician who needs information on cancer and chemoprevention in general without emphasizing on a particular type of cancer or a particular pathway involved in its onset and so on.

Spis treści

Introduction.- Hallmarks of Cancer.- Classification of Cancer.- Factors Influencing Cancer Development.- Carcinogenesis.- Molecular Mechanism of Carcinogenesis.- Oxidative Stress Induced Carcinogenesis.- Major Mediators Linking Inflammation and Cancer.-  Apoptosis.- Chemoprevention.- Classification of Chemopreventive Agents.- Preclinical Development of Chemo Preventive Agents for Chemoprevention.- Modulation of Wnt/β-Catenin Signaling by Chemo Prevention.- Modulation of Akt/mTOR Pathway Signaling by Chemo Prevention.- Novel Chemopreventive Agents.- Chemoprevention by Resveratrol.- Chemoprevention by Genistein.- Chemoprevention by Apigenin.- Chemoprevention by Curcumin.- Chemoprevention by Fisetin.- Chemoprevention by Epigallocatechin-3-gallate (EGCG).- Chemoprevention by Graviola.- Cancer Chemoprevention: Hurdles and Future Prospects and Considerations.- Clinical Trials of Chemoprevention.- Future of Chemoprevention.

O autorze

Dr. Summya Rashid did her PhD from Department of Medical Elementology and Toxicology At Jamia Hamdard University, New Delhi, India and currently she is working as a research associate at the same place. Dr. Rashid has primarily worked on renal cell carcinoma and its various aspects. She possesses more than 5 years of research experience in the field of cancer biology and has contributed in 23 publications with h-index of 7. Dr. Rashid has attended various national and international conferences and workshops. In 2015, she was invited as honorary speaker at the International Conference on Antimicrobial Agents and Chemotherapy" at Valencia, Spain.

In her short scientific career she has received various awards and fellowships. She is also the recipient of prestigious “Meritorious Research Fellowship” by University Grants Commission-Basic Science Research (UGC-BSR) at Molecular Carcinogenesis & Chemoprevention laboratory, Hamdard University, India in April, 2011.

Blurb

This book focuses on the most recent, relevant, comprehensive and significant advances in cancer and chemo prevention. It broadly discusses cancer, its hallmarks and classification, molecular mechanisms of outbreak, contributing factors, role of oxidative stress, inflammatory mediators and evading apoptosis, which leads to the progression of disease.

Though modern medicine has left us with no option to treat this deadly disease due to drawbacks associated with conventional treatment – like its non-targeted nature, drug resistance, varied organ toxicities and unaffordability – chemoprevention offers a viable therapeutic window.

Given chemoprevention’s importance in the present scenario, the book highlights various chemo preventive strategies currently used in the management of cancer; a selection of novel chemo preventive agents used at clinics and in the pre-clinical stage; hurdles to effective chemoprevention; future prospects and the road ahead. It offers a valuable guide for all graduate students and researchers seeking information on cancer and chemoprevention in general, irrespective of the specific type/pathways involved in its onset.