Cancer Prevention: Dietary Factors and Pharmacology

ISBN-13: 9781461492269 / Angielski / Twarda / 2013 / 288 str.

Ann M. Bode; Zigang Dong

Opis

Focused on the discovery of precise molecular targets for the development of the cancer preventive agents, Cancer Prevention: Dietary Factors and Pharmacology provides researchers and non-researchers with practical methodologies for developing and validating small molecule and phytochemical-derived drug discovery and mechanisms by which these compounds can modulate distinct target proteins involved in oncogenic signaling. While this volume is primarily focused toward cancer prevention research, the range of techniques demonstrated in the book also provides an introduction of cancer prevention research methods to researchers outside the field. Chapters deal with a critical discussion of both laboratory and clinical topics, with each chapter containing both a discursive section along with a detailed methods section. As part of the Methods in Pharmacology and Toxicology series, this meticulous volume includes the kind of key implementation advice that seeks to ensure successful results in the lab.Practical and authoritative, Cancer Prevention: Dietary Factors and Pharmacology aims to guide research toward identifying molecular targets and conducting human studies with phytochemicals which would, ideally, provide an enhanced approach to the goal of personalized cancer prevention.

Recenzje

From the reviews:

"The purpose is to provide an overview of the most advanced scientific methods or protocols that are the keys to obtaining knowledge that can be applied in cancer prevention ... . This should be interesting to basic and clinical researchers in cancer prevention and drug development. ... also could be interesting to researchers in the field of cancer treatment and oncogenic signaling. ... It is a good information source for scientific researchers and others who are interested in cancer prevention." (Qi Chen, Doody's Book Reviews, May, 2014)

Spis treści

1. Combining Computational and Experimental Methods for Identifying Molecular Targets of Phytochemicals

            Ann M. Bode and Zigang Dong

 

2. Common Methods Used for the Discovery of Natural Anticancer Compounds

            Min Tang, Xinfang Yu, Yiqun Jiang, Ying Shi, Xiaolan Liu, Wei Li, and Ya Cao

 

3. Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals

            Francisco Fuentes, Limin Shu, Jong Hun Lee, Zheng-Yuan Su, Kyeong-Ryoon Lee, and Ah-Ng Tony Kong

 

4. Methods to Analyze Chemopreventive Effect of Silibinin on Prostate Cancer Biomarkers Protein Expression

            Gagan Deep, Swetha Inturi, and Rajesh Agarwal

 

5. An Approach to the Evaluation of Berries for Cancer Prevention with Emphasis on Esophageal Cancer

            Gary D. Stoner, Li-Shu Wang, Laura A. Kresty, Dan Peiffer, Chieh-Ti Kuo, Yi-Wen Huang, Dian Wang, Ben Ransom, Steven Carmella, and Stephen S. Hecht

 

6. The Use of Mouse Models for Lung Cancer Chemoprevention Studies

            Yian Wang, Michael S. You, Lucina C. Rouggly, and Ming You

 

7. The Azoxymethane Plus Dextran Sulfate Sodium-Induced Mouse Colon Cancer Model for the Study of Dietary Chemoprevention of Inflammation-Associated Carcinogenesis

            Ha-Na Lee, Hye-Won Yum, and Young-Joon Surh

 

8. The Use of Seahorse Extracellular Flux Analyzer in Mechanistic Studies of Naturally-Occurring Cancer Chemopreventive Agents

            Michelle B. Moura, Eun-Ryeong Hahm, Bennett Van Houten, and Shivendra V. Singh

 

9. Utilizing RNA-Seq to Define Phytochemical-Induced Alterations in Insulin and IGF Regulated Transcriptomes

            Heather Beckwith and Douglas Yee

 

10. The Ex Vivo Use of Keratinocytes from Adult Mice to Define Stem Cell Activities in Cancer Research

            Rebecca J. Morris, Nyssa Readio, Kelly M. Johnson, Anupama Singh, Heuijoon Park, Ashok Singh, and Todd F. Schuster

 

11. Quantitation of Acetaldehyde-DNA Adducts: Biomarkers of Alcohol Consumption

            Silvia Balbo and Stephen S. Hecht

 

12. Imaging Tools in Discovery and Development of Phytochemical Chemopreventive Agents

            Marna Ericson

 

13. Designing the Chemoprevention Trials of Tomorrow: Applying Lessons Learned from Past Definitive Trials

            Karen Colbert Maresso and Ernest Hawk