Cancer Nanotechnology: Methods and Protocols

ISBN-13: 9781607616085 / Angielski / Twarda / 2010 / 412 str.

Stephen R. Grobmyer; Brij M. Moudgil

Opis

Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of experts provide the most recent, cutting-edge, "how-to" approaches developed and employed by researchers in a variety of disciplines to identify cancer specific biomarkers, construct suitable multifunctional targeted nanostructure platforms, along with enhanced imaging and therapeutic applications. Covering such topics as multifunctional and multimodal nanoparticles, nanoparticle mediated cancer theranostics, molecular targets for cancer nanotechnology, and nanoparticles for non-invasive image-guided cancer therapy, the volume addresses the key challenges of the field today, specifically targeted and localized delivery of the drugs. As a volume in the highly successful Methods in Molecular Biology series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Nanotechnology: Methods and Protocols integrates cancer biology, clinical oncology, molecular cancer imaging, materials science and chemical engineering, biomedical engineering, toxicology, computer science, electrical engineering, chemistry, physics, and mathematics in order to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for these devastating diseases.

Recenzje

From the reviews:

"This well-illustrated book provides authoritative and cutting-edge reviews on topics such as multifunctional and multimodal nanoparticles, nanoparticle-mediated cancer theranostics, molecular targets for cancer nanotechnology, nanoparticles for noninvasive image-guided cancer therapy, and targeted and localized delivery of the drugs. ... It is intended for both established researchers and those embarking on their maiden research voyage in the field. It will be extremely useful for established investigators, students, clinical oncologists, and others interested in the field of cancer nanotechnology." (Omer Iqbal, Doody's Review Service, August, 2010)

Spis treści

1. What is Cancer Nanotechnology? Stephen R. Grobmyer, Nobutaka Iwakuma, Parvesh Sharma, and Brij M. Moudgil 2. Molecular Targeted Therapy for Cancer and Nanotechnology Steven N. Hochwald 3. Enhanced Permeability and Retention (EPR) Effect for Anticancer Nano-Medicine Drug Targeting Khaled Greish 4. Nanoparticle Characterization for Cancer Nanotechnology and Other Biological Applications Scott C. Brown, Maria Palazuelos, Parvesh Sharma, Kevin W. Powers, Stephen M. Roberts, Stephen R. Grobmyer, and Brij M. Moudgil 5. Multimodal Nanoparticulate Bioimaging Contrast Agents Parvesh Sharma, Amit Singh, Scott C. Brown, Niclas Bengtsson, Glenn A. Walter, Stephen R. Grobmyer, Nobutaka Iwakuma, Swadeshmukul Santra, Edward W. Scott, and Brij M. Moudgil 6. Gold Nanocages for Cancer Imaging and Therapy Leslie Au, Jingyi Chen, Lihong V. Wang, and Younan Xia 7. Nanoshells for Photothermal Cancer Therapy Jennifer G. Morton, Emily S. Day, Naomi J. Halas, and Jennifer L. West 8. Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy Alexander Wei, Alexei P. Leonov, and Qingshan Wie 9. Polymeric Micelles: Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE)-Based Micelles as an Example Rupa R. Sawant and Vladimir P. Torchilin 10. Fluorescent Silica Nanoparticles for Cancer Imaging Swadeshmukul Santra 11. Polymeric Nanoparticles for Drug Delivery Juliana M. Chan, Pedro M. Valencia, Liangfang Zhang, Robert Langer, and Omid C. Farokhzad 12. Synthesis, Characterization, and Functionalization of Gold Nanoparticles for Cancer Imaging Gary A. Craig, Peter J. Allen, and Michael D. Mason 13. Identification of Pancreatic Cancer Specific Cell-Surface Markers for Development of Targeting Ligands David L. Morse, Galen Hostetter, Yoganand Balagurunathan, Robert J. Gillies, and Haiyong Han 14. Preparation and Characterization of Doxorubicin Liposomes Guoqin Niu, Brian Cogburn, and Jeffrey Hughes 15. PEGylated Nanocarriers for Systemic Delivery N.K. Jain and Manoj Nahar 16. Nanoparticle-Aptamer Conjugates for Cancer Cell Targeting and Detection M.-Carmen Estevez, Yu-Fen Huang, Huaizhi Kang, Megan B. O’Donoghue, Suwussa Bamrungsap, Jilin Yan, Xiaolan Chen, and Weihong Tan 17. Targeting of Nanoparticles: Folate Receptor Sumith A. Kularatne and Philip S. Low 18. Magnetic Aerosol Targeting of Nanoparticles to Cancer: Nanomagnetosols Carsten Rudolph, Bernhard Gleich, and Andreas W. Flemmer 19. LHRH-Targeted Nanoparticles for Cancer Therapeutics Tamara Minko, Mahesh L. Patil, Min Zhang, Jayant J. Khandare, Maha Saad, Pooja Chandna, and Oleh Taratula 20. Antibody Targeting of Nanoparticles to Tumor Specific Receptors: Immunoliposomes Miriam Rothdiener, Julia Beuttler, Sylvia K.E. Messerschmidt, and Roland E. Kontermann 21. Photoacoustic Tomography for Imaging Nanoparticles Zhen Yuan and Huabei Jiang 22. Current Applications of Nanotechnology for Magnetic Resonance Imaging of Apoptosis Gustav J. Strijkers, Geralda A.F. van Tilborg, Tessa Geelen, Chris P.M. Reutelingsperger, and Klaas Nicolay 23. Applications of Gold Nanorods for Cancer Imaging and Photothermal Therapy Xiaohua Huang, Ivan H. El-Sayed, and Mostafa A. El-Sayed 24. Use of Nanoparticles for Targeted, Noninvasive Thermal Destruction of Malignant Cells Paul Cherukuri and Steven A. Curley 25. Colloidal Gold: A Novel Nanoparticle for Targeted Cancer Therapeutics Anathea C. Powell, Giulio F. Paciotti, and Steven K. Libutti 26. Liposomal Doxorubicin and