Cancer Nanotechnology: Methods and Protocols

ISBN-13: 9781493966448 / Angielski / Twarda / 2017 / 414 str.

Reema Zeineldin

Opis

This detailed volume presents protocols for advancing the utility of nanotechnology in cancer research toward improving our understanding of cancer biology, prevention, diagnosis, and therapy. There are continuous new discoveries in the field of nanotechnology, thus creating new imaging systems or therapies, and this book focuses on how to employ certain discoveries for studying cancer by presenting principles along with techniques to allow for the transformation of any new discoveries in the field into cancer-studying tools with the hope of bringing in the involvement of biomedical scientists who can enhance the speed of discoveries toward cancer diagnosis and therapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and motivating, Cancer Nanotechnology: Methods and Protocols serves as an ideal resource for biomedical scientists interested in the potential of this field as well as for physical scientists and engineers interested in employing nanotechnology in cancer diagnosis and therapy.

Spis treści

Part I: Overviews

 

1. Cancer Nanotechnology: Opportunities for Prevention, Diagnosis, and Therapy

            Reema Zeineldin and Joan Syoufjy

 

2. Improved Targeting of Cancers with Nanotherapeutics

            Christian Foster, Andre Watson, Joseph Kaplinsky, and Nazila Kamaly

 

Part II: Nanotechnology-Based Platforms

 

3. Multifunctional Liposomes

            Bhawani Aryasomayajula, Giuseppina Salzano, and Vladimir P. Torchilin

 

4. Multifunctional Concentric FRET-Quantum Dot Probes for Tracking and Imaging of Proteolytic Activity

            Melissa Massey, Jia Jun Li, and W. Russ Algar

 

5. Preparation and Characterization of Magnetic Nano-in-Microparticles for Pulmonary Delivery

            Amber A. McBride, Dominique N. Price, and Pavan Muttil

 

6. Multifunctionalization of Gold Nanoshells

            Sandra W. Bishnoi and Yujen Lin

 

7. Fabrication of Photothermal Stable Gold Nanosphere/Mesoporous Silica Hybrid Nanoparticle Responsive to Near-Infrared Light

            Bei Cheng and Peisheng Xu

 

8. Engineering Well-Characterized PEG-Coated Nanoparticles for Elucidating Biological Barriers to Drug Delivery

            Qi Yang and Samuel K. Lai

 

9. Piloting Your Nanovehicle to Overcome Biological Barriers

            Steven M. Richards and Robert B. Campbell

 

10. Detecting Sonolysis of Polyethylene Glycol Upon Functionalizing Carbon Nanotubes

            Ruhung Wang, Vasanth S. Murali, and Rockford Draper

 

11. Methods for Generation and Detection of Non-Stationary Vapor Nanobubbles Around Plasmonic Nanoparticles

            Ekaterina Y. Lukianova-Hleb and Dmitri O. Lapotko

 

Part III: Nanotechnology to Study Cancer

 

12. Force Measurements for Cancer Cells

            Vivek Rajasekharan, Varun K.A. Sreenivasan, and Brenda Farrell

 

13. Fractal Analysis of Cancer Cell Surface

            Igor Sokolov and Maxim E. Dokukin

 

14. Quantitative Evaluation of the Enhanced Permeability and Retention (EPR) Effect

            Luisa M. Russell, Charlene M. Dawidczyk, and Peter C. Searson

 

Part IV: Nanotechnology for Prevention and Detection/Imaging of Cancer

 

15. Nanotechnology-Based Cancer Vaccines

            Aws Alshamsan

 

16. Designing Multicomponent Nanosystems for Rapid Detection of Circulating Tumor Cells

            Shashwat S. Banerjee, Vrushali Khobragade, and Jayant Khandare

 

17. Fluorescence and Bioluminescence Imaging of Orthotopic Brain Tumors in Mice

            Emilie McKinnon, Alfred Moore, Suraj Dixit, Yun Zhu, and Ann-Marie Broome

 

18. An Ultrasensitive Biosensing Platform Employing Acetylcholinesterase and Gold Nanoparticles

            Dingbin Liu and Xiaoyuan Chen

 

Part V: Nanotechnology-Based Therapies

 

19. Gene Silencing Using Multifunctionalized Gold Nanoparticles for Cancer Therapy

            Alexandra R. Fernandes and Pedro V. Baptista

 

20. Generation of Dose Response Curves and Improved IC50’s for PARP Inhibitor Nanoformulations

            Paige Baldwin, Shifalika Tangutoori, and Srinivas Sridhar

 

21. Artificial Antigen-Presenting Cells for Immunotherapies

            Alyssa L. Siefert, Tarek M. Fahmy, and Dongin Kim

 

22. Exploiting Uptake of Nanoparticles by Phagocytes for Cancer Treatment<

            Mee Rie Sheen and Steven Fiering

 

23. Pulmonary Delivery of Magnetically-Targeted Nano-in-Microparticles

            Amber A. McBride, Dominique N. Price, and Pavan Muttil

 

24. Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy

            Derek Hargrove and Xiuling Lu

 

25. Nanoparticle-Mediated X-Ray Radiation Enhancement for Cancer Therapy

            Autumn D. Paro, Ilanchezhian Shanmugam, and Anne L. van de Ven

 

26. Radiosensitizing Silica Nanoparticles Encapsulating Docetaxel for Treatment of Prostate Cancer

            Jodi Belz, Noelle Castilla-Ojo, Srinivas Sridhar, and Rajiv Kumar