Cancer Metabolomics: Methods and Applications

ISBN-13: 9783030516512 / Angielski / Twarda / 2021 / 312 str.

Shen Hu

Spis treści

1. NMR-Based Metabolomics in Cancer Research

2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics

3. Chemical Isotope Labeling LC-MS for Metabolomics

4. Single cell metabolomics by mass spectrometry imaging

5. Fatty Acid Metabolism and Cancer

6. Metabolomics of Gastric Cancer

7. HIF-1α metabolic pathways in human cancer

8. Regulation of glycolysis in head and neck cancer

9. Metabolomics of oral/head and neck cancer

10. Ion chromatography with mass spectrometry for metabolomic analysis

11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids

12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy

13. Metabolomics of glioma

14. Microbial metabolomics: From methods to translational applications

15. Advances in the study of N6-methyladenine in eukaryotes

16. NMR Based Metabolomics

17. Quantitative analysis of oncometabolite 2-hydroxyglutarate

18. Tracer-based Cancer Metabolomic Analysis

19. Mass spectrometry-based shotgun lipidomics for cancer research

20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics

O autorze

Dr. Shen Hu is a Professor at the University of California, Los Angeles, and currently directs the Oral Biology Graduate Program. He received his PhD in Bioanalytical Chemistry from Wuhan University and MBA from the Anderson School of Management at the University of California, Los Angeles. Dr. Hu’s research interests are in cancer metabolomics, stem cell biology and single cell analysis. His laboratory is developing diagnostic tools for early cancer detection and therapeutic drugs targeting the metabolic pathways of cancer. 

Blurb

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics.  In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.