Cancer Immunotherapy

ISBN-13: 9786202524537 / Angielski / Miękka / 2020 / 116 str.

Imliwati Longkumer

Opis

Chemically induced tumors in mice provide a system to investigate tumor-associated antigens (TAA). The cell surface glycoprotein antigens on such tumor cells have been identified as suitable targets for immune attack. The induction of immune responses against TAA in N-nitrosodiethylamine (DEN) has been examined. In order to present antigens to the immune system, the liposome was used as vehicle to deliver the TAA. Liposomal-TAA formulation, elicited both humoral and the cellular immune responses, when administered intramuscularly in DEN-exposed mice. Presence of circulatory antibodies against TAA and the induction of cellular responses in immunized mice were monitored using ELISA and in vitro cell proliferation assay of lymphocytes respectively. Specificity of antibody against TAA in immune sera was analysed using immunoblotting technique. Based on these results, it is proposed that the liposome encapsulated TAA may successfully be used to induce humoral and cellular responses against tumor.

O autorze

Longkumer, Imliwati
Imliwati Longkumer born in Impur, Nagaland state, India. He studied biological science and completed his doctoral degree in biochemistry in 2000 from North Eastern Hill University, Shillong. Currently, he is practicing as a biochemist and pursuing cancer research at North East Cancer Hospital and Research Institute, Guwahati in Assam.