Cancer Immunology

ISBN-13: 9789048157143 / Angielski / Miękka / 2010 / 253 str.

R. a. Robins; R. C. Rees

Opis

This publication provides a comprehensive account of the known groups of human tumour antigens, and the immune effector cells involved in tumour rejection. Chapters dealing with all the major groups of human tumour antigens are included, covering differentiation antigens, testes-associated antigens, CEA, mucin, viral antigens, anti-idiotypic antibodies as antigens, and fusion proteins. The role of heat shock proteins as mediators of tumour immunity is discussed and consideration is given to the immune mechanisms which mediate tumour rejection in both human and animal systems. The application of antibody targeting to identify cancers, and the mechanisms by which tumours evade immune detection and/or destruction is covered in detail. Although the focus of this publication is experimental, as with other recent publications progress in clinical immunotherapy is included in some detail, to provide postgraduate and post-doctoral scientists with in-depth reviews of the field.

Spis treści

Contributers. 1. Immunogenicity of tumour associated antigens; S. Mian, et al. 2. Recognition of human tumours: cancer/testis antigens; A.F. Kirkin, et al. 3. Recognition of human tumors: SEREX expression cloning to identify tumour antigens; U. Sahin, et al. 4. Recognition of human tumours: melanoma differentiation antigens; J. Zeuthen, A.F. Kirkin. 5. Carcinoembryonic Antigen as a Vaccine Target; J. Schlom, et al. 6. MUC1 mucin as a target for immunotherapy of cancer: Muc1 based immunotherapeutic strategies; M. Soares, O.J. Finn. 7. Recognition of human tumours: viral antigens as immunological targets for cytotoxic T Cells; S. Man. 8. The immune response to oncogenic fusion proteins; L. Passoni, C. Gambacorti-Passerini. 9. Immunological significance of hsp70 in tumor rejection; A. Ménoret. 10. Anti-idiotypic vaccination; L.G. Durrant, et al. 11. Genetically modified tumour cells for cancer immunization; S. Todryk, et al. 12. Antibody targeted therapy; delivery of radionuclides, toxins and drugs; A. Murray, et al. 13. Escape mechanisms in tumour immunity; G. Pawelec. Index.