Cancer Genome and Tumor Microenvironment

ISBN-13: 9781441907103 / Angielski / Twarda / 2009 / 480 str.

Andrei Thomas-Tikhonenko

Opis

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are "soft-wired," i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.

Recenzje

From the reviews:

"This book compiles recent works on genetic alterations that have been associated with carcinogenesis and attempts to present these in the context of the interaction of tumor cells with their microenvironment. The book provides a great deal of information on specific subjects of research, and is very useful as a reference. ... The audience includes scientists and physicians involved in basic and translational research." (Khashayarsha Khazaie, Doody's Review Service, July, 2010)

"This book amends a space of nowaday cancer bibliography in the area of tumor microenvironment as it provides detailed overview of crucial steps of tumorigenesis. Book consists of 20 chapters that are divided into 4 main parts in addition to introductory editor's part providing short characteristics of particular chapters and closing one. ... The book is very useful for PhD students and for all researchers who intend to be more oriented in advances of molecular oncology. Therefore the book is highly recommended." (J. Sedlák, Neoplasma, February, 2011)

Spis treści

Part One: Opening remarks Hardwiring tumor progression (Andrei Thomas-Tikhonenko) Part Two: Breaking away: Epithelial-mesenchymal transition PI3K/AKT pathway and the epithelial-mesenchymal transition (Alfonso Bellacosa and Lionel Larue) Loss of cadherin-catenin adhesion system in invasive cancer cells (Wen-Hui Lien and Valeri Vasioukhin) Rho GTPases in regulation of cancer cell motility, invasion, and microenvironment (Donita Brady, Jamie Alan, and Adrienne Cox) Merlin/NF2 tumor suppressor and Ezrin-Radixin-Moesin (ERM) proteins in cancer development and progression (Ling Ren and Chand Khanna) Part Three: Coming up for air: Hypoxia and Angiogenesis von Hippel–Lindau tumor suppressor, hypoxia-induced factor-1, and tumor vascularization (Huafeng Zhang and Gregg Semenza) RAS oncogenes and tumor-vascular interface (Janusz Rak) Myc and control of tumor neovascularization (Prema Sundaram, Chi V. Dang, and Andrei Thomas-Tikhonenko) p53 and angiogenesis (Jose Teodoro, Sara Evans, and Michael Green) Ink4a locus: beyond cell cycle (Gregory Enders) Part Four: Gaining new ground: Metastasis and stromal cell interactions NM23 as a metastasis inhibitor (Rajeev Kaul, Masanao Murakami, Pankaj Kumar, and Erle Robertson) HGF/c-MET signaling in advanced cancers (Mandira Ray, JG Garcia, and Ravi Salgia) Contribution of ADAMs and ADAMTSs to tumor expansion and metastasis (Antoni Xavier Torres-Collado and Luisa Iruela-Arispe) Stromal cells & tumor milieu: PDGF et al (Michele Jacob and Ellen Puré) Tgf-beta signaling alterations in neoplastic and stromal cells (Qinghua Zeng and Boris Pasche) Part Five: Getting attention: Immunerecognition and inflammation Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers (Antonia Sepulveda and John Lynch) Immunoglobulin gene rearrangements, oncogenic translocations, B-cell receptor signaling, and B-lymphomagenesis (Murali Gururajan and Subbarao Bondada) Modulation of Philadelphia chromosome-positive hematological malignancies by bone marrow microenvironment (Lin Wang, Heather O’Leary, and Laura Gibson) Part 6: Putting it all together Melanoma: mutations in multiple pathways at the tumor-stroma interface (Himabindu Gaddipati and Meenhard Herlyn) Cooperation and Cancer (Kathleen Sprouffske and Carlo Maley, Wistar Institute)

Blurb

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled.