Cancer Gene Therapy

ISBN-13: 9781588292131 / Angielski / Twarda / 2004 / 490 str.

David T. Curiel; Joanne Douglas; David T. Ed Curiel

Opis

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Recenzje

"...represents an outstanding work, which should not be missed in all laboratories dealing with cancer gene therapy." - Neoplasma

Spis treści

Cancer Gene Therapy: Historical Perspective Malcolm K. Brenner The Genetic Basis of Cancer Akseli Hemminki and Kari Hemminki Tumor Suppressor Gene Replacement for Cancer Jack A. Roth and Susan F. Grammer Antisense Technology Ruiwen Zhang and Hui Wang Cancer Therapeutic Applications of Ribozymes and RNAi Lisa Scherer and John J. Rossi. Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy: A Better Class of Killer Andrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, and Richard Vile Suicide Gene Therapy Caroline J. Springer and Ion Niculescu-Duvaz Molecular Chemotherapy Approaches Daniel H. Palmer and David J. Kerr Genetic Immunotherapy Approaches Denise R. Shaw and Albert F. LoBuglio Immunotherapy of Cancer By Dendritic Cell-Targeted Gene Transfer Tanja D. de Gruijl, Herbert M. Pinedo, and Rik J. Scheper. Dendritic Cells Weiping Zou, Shuang Wei, and Tyler J. Curiel Polynucleotide Immunization for Cancer Therapy Theresa V. Strong Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors: The G207 Paradigm Tomoki Todo and Samuel D. Rabkin Development of Oncolytic Adenoviruses: From the Lab Bench to the Bedside John A. Howe, Robert Ralston, and Murali Ramachandra Conditionally Replicating Adenoviruses for Cancer Treatment Ramon Alemany Reovirus as an Oncolytic Agent Megan K. Patrick, Kara L. Norman, and Patrick W. K. Lee Antiangiogenic Gene Therapy of Cancer Steve Gyorffy, Jack Gauldie, A. Keith Stewart, and Xiao-Yan Wen Proapoptotic Strategy in Cancer Gene Therapy David H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, and James S. Norris Antimetastasis Duen-Hwa Yan, Kung-Ming Rau, and Mien-Chie Hung Antimetastatic Gene Therapy: Prostate Cancer Theory to Therapy Thomas A. Gardner, Juan Antonio Jiménez, Leland W. K. Chung, and Chinghai Kao Drug Resistance Gene Transfer as an Antitumor Strategy Colin L. Sweeney and R. Scott McIvor Chemosensitization Per Eystein Lønning Radiosensitization by Gene Therapy Steven J. Chmura, Michael Garofalo, and Ralph R. Weichselbaum Nonviral Vector Systems for Cancer Gene Therapy Greg F. Walker and Ernst Wagner Viral Vectors for Cancer Gene Therapy Joanne T. Douglas and David T. Curiel Bacterial Systems for Tumor-Specific Gene Therapy J. Martin Brown, Shie-Chau Liu, Jan Theys, and Philippe Lambin Molecular Imaging of Cancer Gene Therapy Harvey R. Herschman Cancer-Related Gene Therapy Clinical Trials Robert J. Korst and Ronald G. Crystal Regulatory Aspects in the Development of Gene Therapies Rosemarie Aurigemma, Joseph E. Tomaszewski, Sheryl Ruppel, Stephen Creekmore, and Edward A. Sausville Index

Blurb

Today a new generation of powerful cancer therapeutics targeted against the molecular pathways that produce malignant phenotypes is rapidly emerging. In Cancer Gene Therapy, leading basic and clinical cancer oncologists provide a complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. In their discussions, the authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Authoritative and wide ranging, Cancer Gene Therapy offers a comprehensive survey of the molecular basis of cancer gene therapy and demonstrates its enormous potential to take a place in the clinic alongside the current generation of anticancer therapeutics.