Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis

ISBN-13: 9781493948949 / Angielski / Miękka / 2016 / 804 str.

Mukesh Verma

Opis

This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results.Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.

Spis treści

Part I: Background: Epigenetic Mechanism

 

1. Cancer Epigenetics: An Introduction

            Rajnee Kanwal, Karishma Gupta, and Sanjay Gupta

 

2. Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program

            John S. Satterlee, Andrea Beckel-Mitchener, Kim McAllister, Dena C. Procaccini, Joni L. Rutter, Frederick L. Tyson, and Lisa Helbling Chadwick

 

3. Epigenome-Wide Association Studies (EWAS): Past, Present, and Future

            James M. Flanagan

 

4. Epigenetic Biomarkers in Liver Cancer

            Krishna K. Banaudha and Mukesh Verma

 

Part II: Cancer Specific Type Epigenetic Changes

 

5. Cancer Type Specific Epigenetic Changes: Gastric Cancer

            Danielle Queiroz Calcagno, Marília de Arruda Cardoso Smith, and Rommel Rodriguez Burbano

 

6. Beyond the Island: Epigenetic Biomarkers of Colorectal and Prostate Cancer

            Andrea J. Savio and Bharati Bapat

 

7. Prostate Cancer Epigenome

            Swathi Chinaranagari, Pankaj Sharma, Nathan J. Bowen, and Jaideep Chaudhary

 

8. CpG Island Hypermethylation as a Biomarker for the Early Detection of Lung Cancer

            Yujin Kim and Duk-Hwan Kim

 

9. Analysis of DNA Methylation in Pancreatic Cancer: An Update

            Christian Pilarsky and Robert Grützmann

 

10. Epigenetics of Urothelial Carcinoma

            Wolfgang A. Schulz, Evangelia A. Koutsogiannouli, Günter Niegisch, and Michèle J. Hoffmann

 

11. Epigenetics of Prostate Cancer

            Tawnya C. McKee and James V. Tricoli

 

12. Methylation Profile Landscape in Mesothelioma: Possible Implications in Early Detection, Disease Progression, and Therapeutic Options

            Xinbo Zhang, Naimei Tang, Arun K. Rishi, Harvey I. Pass, and Anil Wali

 

Part III: Methods and Technologies Used for Detecting Epigenetic Changes

 

13. Techniques to Access Histone Modifications and Variants in Cancer

            Monica Tyagi, Shafqat A Khan, Saikat Bhattacharya, Divya Reddy, Ajit K Sharma, Bharat Khade,  and Sanjay Gupta

 

14. Single Base Resolution Analysis of 5-Methylcytosine and 5-Hydroxymethylcytosine by RRBS and TAB-RRBS

            Maria A. Hahn, Arthur X. Li, Xiwei Wu, and Gerd P. Pfeifer

 

15. Quantitative DNA Methylation Analysis for Epigenotyping of Colorectal Cancer

            Atsushi Kaneda and Koichi Yagi

 

16. Histone Modifications Associated with Cancer Cell Migration and Invasion

            Miki Hieda, Nariaki Matsuura, and Hiroshi Kimura

 

Part IV: Factors that Influence Epigenetic Changes in Cancer

 

17. Aberrant Epigenetic Modifications in Radiation-Resistant Head and Neck Cancers

            Hon-Yi Lin, Tim Hui-Ming Huang, and Michael Wing-Yan Chan

 

18. Cancer-Associated Infectious Agents and Epigenetic Regulation

            Vidya Vedham and Mukesh Verma

 

19. Toxicoepigenomics and Cancer: Implications for Screening

            Mukesh Verma

 

20. Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome

            Josena K. Stephen and Maria J. Worsham

 

21. Epigenetic Regulation of HIV, AIDS, and AIDS-Related Malignancies

            Mukesh Verma

 

22. Epigenetics of Colorectal Cancer

            Wenji Yan and Mingzhou Guo

 

23. Epigenetics in Breast and Prostate Cancer

            Yanyuan Wu, Marianna Sarkissyan, and Jaydutt V. Vadgama

 

Part V: Future Directions: Risk Assessment, Diagnosis, Treatment, and Prognosis

 

24. Epigenetic Inhibitors

            Mukesh Verma and Hirendra Nath Banerjee

 

25. Use of Epigenetic Modulators as a Powerful Adjuvant for Breast Cancer Therapies

            Aurore Claude-Taupin, Michael Boyer-Guittaut, Régis Delage-Mourroux, and Eric Hervouet

 

26. Epigenetic Approaches in Glioblastoma Multiforme and Their Implication in Screening and Diagnosis

            Gwyneth Hyman, Vinod Manglik, Jeffrey M. Rousch, Mukesh Verma, David Kinkebiel, and Hirendra Nath Banerjee

 

27. Detection of Circulatory MicroRNAs in Prostate Cancer

            Anvesha Srivastava, Helle Goldberger, Zainab Afzal, Simeng Suy, Sean P. Collins, and Deepak Kumar

 

28. Identification and Characterization of Small-Molecule Inhibitors of Lysine Acetyltransferases

            Daiqing Liao

 

29. Epigenetic Regulation in Biopsychosocial Pathways

            Kristin Litzelman and Mukesh Verma

 

30. Viral Epigenetics

            Barry I. Milavetz and Lata Balakrishnan

 

31. P53 Tumor Suppression Network in Cancer Epigenetics

            Alok Mishra, Daniel J. Brat, and Mukesh Verma

 

32. Promoter Hypermethylation as a Biomarker in Prostate Adenocarcinoma

            Jong Y. Park

 

33. Sequencing the Cancer Methylome

            Austin Y. Shull, Satish K. Noonepalle, Eun-Joon Lee, Justin Choi, and Huidong Shi

 

34. Global DNA Methylation Profiling Technologies and the Ovarian Cancer Methylome

            Jessica Tang, Fang Fang, Dave F. Miller, Jay M. Pilrose, Daniela Matei, Tim H.-M. Huang, and Kenneth P. Nephew

 

35. Recent Progress in the Discovery of Epigenetic Inhibitors for the Treatment of Cancer

            Sharad K. Verma

 

36. At the Crossroad Between Obesity and Gastric Cancer

            Robert B. Uddo, Jone Garai, Maura C. Mohler, Nicole Pelligrino, Richard Scribner, Melinda S. Sothern, and Jovanny Zabaleta

 

37. Detection of Epigenetic Aberrations in the Development of Hepatocellular Carcinoma

            Yujing Zhang

 

38. Specific Type Epigenetic Changes in Cervical Cancers

            Shuping Zhao

 

39. Epigenetics in Head and Neck Cancer

            Syeda Marriam Bakhtiar, Amjad Ali, and Debmalya Barh

 

40. Epigenetic Therapy for Colorectal Cancer

            Vivek Vaish, Tripti Khare, Mukesh Verma, and Sharad Khare