Cancer Epigenetics

ISBN-13: 9781420045796 / Angielski / Twarda / 2008 / 472 str.

Trygve Tollefsbol

Opis

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers

DNA methylation and cancer

Histone modifications in cancer

Emerging areas of cancer epigenetics

Epigenetics in the diagnosis, prognosis, and therapy of cancer

Future directions in epigenetic cancer research

Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field."

Spis treści

The Role of Epigenetics in Cancer. DNA Hypomethylation in Cancer. DNA Hypermethylation in Oncogenesis. Imprinting Alterations in Tumorigenesis. Proteins that Modulate DNA Methylation Aberrations in Cancer. The Role of DNA Methylation in Cancer Progression. Alterations in Histone Acetylation in Tumorigenesis. Histone Methylation and the Initiation of Cancer. The Role of Sirtuins in Aging and Tumorigenesis. Proteins that Alter Histone Modifications in Cancer. Dietary and Environmental Influences on Histone Modifications in Cancer. Noncoding RNAs in Cancer. Cancer-linked DNA Hyper- and Hypomethylation: Chromosome Positional Effects. Chromatin Remodeling and Cancer. Poly-ADP-ribosylation in Cancer. Polycomb Group Proteins in Tumorigenesis. Cancer and Aging: The Epigenetic Connection.  DNA Methylation in Tumor Diagnosis. DNA Methylation Profiles as Prognostic Markers for Cancer. Diagnosing Cancer Using Histone Modification Analysis. Histone Modifications in Cancer Biology and Prognosis. Histone Deacetylase Inhibitors in Cancer Therapy. Methylation Changes in Neoplasia: Diagnostic and Therapeutic Implications. Clinical Trials and Approved Drugs for Epigenetic Cancer Therapy. Future Directions in Epigenetic Cancer Research.

O autorze

Trygve Tollefsbol