Cancer Epigenetics

ISBN-13: 9780367386863 / Angielski / Miękka / 2019 / 472 str.

Trygve Tollefsbol

Opis

The realization that heredity is not the sole determining factor in disease development recently sparked interest in the field of epigenetics, which is now the focus of many of the most exciting and significant advances in cancer research. This important and highly relevant text presents in-depth discussions of DNA methylation analysis and cancer, histone modifications and cancer, and other epigenetic aspects of cancer. It explores the role of epigenetics in the diagnosis, prognosis, and therapy of cancer and offers a comprehensive overview of current and potential new epigenetics advancements.

Spis treści

The Role of Epigenetics in Cancer. DNA Hypomethylation in Cancer. DNA Hypermethylation in Oncogenesis. Imprinting Alterations in Tumorigenesis. Proteins that Modulate DNA Methylation Aberrations in Cancer. The Role of DNA Methylation in Cancer Progression. Alterations in Histone Acetylation in Tumorigenesis. Histone Methylation and the Initiation of Cancer. The Role of Sirtuins in Aging and Tumorigenesis. Proteins that Alter Histone Modifications in Cancer. Dietary and Environmental Influences on Histone Modifications in Cancer. Noncoding RNAs in Cancer. Cancer-linked DNA Hyper- and Hypomethylation: Chromosome Positional Effects. Chromatin Remodeling and Cancer. Poly-ADP-ribosylation in Cancer. Polycomb Group Proteins in Tumorigenesis. Cancer and Aging: The Epigenetic Connection.  DNA Methylation in Tumor Diagnosis. DNA Methylation Profiles as Prognostic Markers for Cancer. Diagnosing Cancer Using Histone Modification Analysis. Histone Modifications in Cancer Biology and Prognosis. Histone Deacetylase Inhibitors in Cancer Therapy. Methylation Changes in Neoplasia: Diagnostic and Therapeutic Implications. Clinical Trials and Approved Drugs for Epigenetic Cancer Therapy. Future Directions in Epigenetic Cancer Research.

O autorze

Trygve Tollefsbol