Calcium in Drug Action

ISBN-13: 9781468433562 / Angielski / Miękka / 2012 / 366 str.

G. B. Weiss; G. B. Weiss

Opis

Anyone surveying physiological and pharmacological journals can readily see that the biological actions of calcium ion are of increasingly widespread current interest. The scope of investi gated actions and reactions in which a role for calcium ion is of some importance is so numerous as to convey the impression that calcium ion is everywhere and interacts with everything. This being so, the challenge in contemporary research is to focus on investigation of those actions of calcium ion which, in some manner, influence either significant physiological parameters or the manner in which pharmacological agents act. This multi-authored book originated from a more limited Symposium on "Importance of Calcium as a Primary Locus of Drug Action" co-chaired by myself and Dr. Frank R. Goodman at the April, 1977 FASEB meeting in Chicago. This Symposium was organized in response to a perceived need for increased communication among 2 workers in different areas of Ca +-related research. In the pro cess of selecting the maximum of six areas for presentation within the format provided, it soon became apparent that this would result in only a limited sampling of current research efforts. Expansion of the number of areas to fourteen within a book format appeared to be the most logical mechanism to provide a more coherent inter disciplinary approach to consideration of various aspects of the 2 roles of Ca + in drug action. This is not to imply that all rele 2 vant Ca +-related areas are surveyed within this volume."

Spis treści

Section I. Analysis and Alteration of calcium Ion Distribution and Movements.- 1. Calcium, Calcium Translocation and Specific Calcium Antagonists.- 2. Surface Calcium in the Heart: Its Function and Role in Drug Action.- 3. Quantitative Measurement of Binding Sites and Washout Components for Calcium Ion in Vascular Smooth Muscle.- 4. Calcium in Smooth Muscle Function.- Section II. Subcellular Sites and Interactions: Calcium and Drugs.- 5. Effects of Calcium on Adenylate Cyclase, as Part of the Ca2+-cAMP Feedback in Biological Communication.- 6. Prostaglandins, Calcium and Cyclic Nucleotides in Stimulus-Response Coupling.- 7. Regulation of Calcium by Vascular Smooth Muscle Cellular Components.- 8. Role of Calcium in the Actions of Agents Affecting Membrane Permeability.- Section III. Calcium in Drug Action: Some Specific Biological Systems.- 9. The Role of Calcium in Blood Platelet Function.- 10. Effects of Opiate Drugs on the Metabolism of Calcium in Synaptic Tissue.- 11. Calcium and Neuromuscular Transmission.- 12. Role of Calcium in Desensitization at the Motor End-Plate of Skeletal Muscle.- 13. Effect of Pharmacological Agents on Calcium Stores in Amphibian Fast and Slow Muscle Fibers.- 14. Calcium Related Basis of Action of Vascular Agents: Cellular Approaches.